Park Hye-Kyung, Cheng Kai-Chung, Tetteh Afua O, Hildemann Lynn M, Nadeau Kari C
a Division of Pulmonary and Critical Care, Department of Medicine, Stanford University School of Medicine , Stanford , CA , USA.
b Civil and Environmental Engineering Department , Stanford University , Stanford , CA , USA.
J Asthma. 2017 May;54(4):341-346. doi: 10.1080/02770903.2016.1218011. Epub 2016 Oct 10.
Epidemiologic studies indicate that indoor air pollution is correlated with morbidity caused by allergic diseases. We evaluated the effectiveness of reducing the levels of indoor fine particulate matter <2.5 micrometer diameter (PM) in Fresno, California using air purifiers on health outcomes in children with asthma and/or allergic rhinitis.
The active group (with air purifiers) and the control group consisted of eight houses each. Air purifiers were installed in the living rooms and bedrooms of the subjects in the active group during the entire 12-week study duration. Childhood asthma control test, peak flow rate monitoring, and nasal symptom scores were evaluated at weeks 0, 6, and 12.
At 12 weeks, the active group showed a trend toward an improvement of childhood asthma control test scores and mean evening peak flow rates, whereas the control group showed deterioration in the same measures. Total and daytime nasal symptoms scores significantly reduced in the active group (p = 0.001 and p = 0.011, respectively). The average indoor PM concentrations reduced by 43% (7.42 to 4.28 μg/m) in the active group (p = 0.001).
Intervention with air purifiers reduces indoor PM levels with significant improvements in nasal symptoms in children with allergic rhinitis in Fresno.
流行病学研究表明，室内空气污染与过敏性疾病所致发病率相关。我们评估了在加利福尼亚州弗雷斯诺使用空气净化器降低室内直径小于2.5微米的细颗粒物（PM）水平对哮喘和/或过敏性鼻炎儿童健康结局的影响。
实验组（配备空气净化器）和对照组各有八所房屋。在为期12周的整个研究期间，空气净化器安装在实验组受试者的客厅和卧室。在第0、6和12周评估儿童哮喘控制测试、峰值流速监测和鼻部症状评分。
在第12周时，实验组儿童哮喘控制测试分数和平均夜间峰值流速呈改善趋势，而对照组在相同指标上出现恶化。实验组的鼻部总症状评分和日间症状评分显著降低（分别为p = 0.001和p = 0.011）。实验组室内PM平均浓度降低了43%（从7.42降至4.28μg/m）（p = 0.001）。
使用空气净化器进行干预可降低室内PM水平，并显著改善弗雷斯诺过敏性鼻炎儿童的鼻部症状。
