State Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University.
Asian Pac J Allergy Immunol. 2018 Dec;36(4):217-221. doi: 10.12932/AP-010717-0109.
With the rising prevalence of allergic rhinitis, the utility of indoor environmental management deserves increasing scrutiny. This research aims at evaluating the ability of air purifiers to be a therapy of allergic rhinitis.
32 subjects (25±13.5 years old) diagnosed with allergic rhinitis were selected and HEPA air purifiers placed in their bedrooms for 4 months. Before the intervention and each month, dust samples were collected with a vacuum cleaner and the dust collector assessed for allergen content. Additionally, static dust collectors were left in place all month to collect dust by sedimentation. Particulate matter (PM) was assessed in terms of PMindoor/outdoor ratios. The Rhinitis Quality of Life Questionnaire (RQLQ) was used to assess symptoms.
Der p 1 (78 (30,82) ng/g) was the dominant dust mite allergen in air samples of patients' bedroom as well as static collections. Der f1 (444 (345,667) ng/g) was the dominant allergen in bedding. Der f1 levels in both air and bed sampling significantly decreased after initiation of HEPA air purifiers (P<0.05). PM1.0indoor/outdoor, PM2.5indoor/outdoor, PM10indoor/outdoor all decreased (P<0.001) with the HEPA filtration intervention. According to RQLQ data, HEPA filtration was associated with improvements in activity limitation, non-nasal-eye symptoms, practical problems, and nasal symptoms (P<0.001).
HEPA air purifiers can effectively reduce PM and HDM allergen concentration in the indoor air, and thereby improve clinical manifestations of patients with AR.
随着过敏性鼻炎的患病率不断上升，室内环境管理的效用值得进一步研究。本研究旨在评估空气净化器治疗过敏性鼻炎的效果。
选择 32 名（25±13.5 岁）确诊为过敏性鼻炎的患者，在其卧室中放置高效空气净化器（HEPA）4 个月。在干预前和每个月，使用吸尘器采集灰尘样本，并评估集尘器中的过敏原含量。此外，静态集尘器整个月都留在原处，通过沉降收集灰尘。以室内/室外颗粒物（PM）比值评估 PM。使用鼻炎生活质量问卷（RQLQ）评估症状。
尘螨过敏原中，屋尘螨 Der p 1（78（30，82）ng/g）是患者卧室空气样本和静态收集物中的主要过敏原。屋尘螨 Der f1（444（345，667）ng/g）是床上用品的主要过敏原。启动 HEPA 空气净化器后，空气中和床上采集的尘螨过敏原 Der f1 水平均显著降低（P<0.05）。使用 HEPA 过滤干预后，PM1.0 室内/室外、PM2.5 室内/室外、PM10 室内/室外比值均降低（P<0.001）。根据 RQLQ 数据，HEPA 过滤与活动受限、非鼻眼症状、实际问题和鼻部症状的改善相关（P<0.001）。
HEPA 空气净化器可有效降低室内空气中的 PM 和 HDM 过敏原浓度，从而改善 AR 患者的临床表现。
