Dezayee Zhian Mahmood Ibrahim, Al-Nimer Marwan Salih Mohamad
Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
Indian J Dent Res. 2016 Jul-Aug;27(4):388-391. doi: 10.4103/0970-9290.191887.
Human C-reactive protein (CRP) has been used in the risk assessment of coronary events. Human saliva mirrors the body's health and well-being and is noninvasive, easy to collect, and ideal for third-world countries as well as for large patient screening.
This study aimed to screen the saliva CRP qualitatively in patients with diabetes (Type 1 and 2) taking in considerations, the diagnostic criteria of metabolic syndrome.
Center for diabetes mellitus, prospective study.
A total number of 50 Type 2 diabetes (T2D) patients, 25 Type 1 diabetes (T1D) patients, and 25 healthy subjects were recruited from the center for diabetes mellitus. Each patient was assessed clinically, and the anthropometric measures, glycemic status, and lipid profiles were determined. Stimulated salivary flow rate and saliva CRP were determined.
All calculations analysis was made using Excel 2003 program for Windows.
The results showed that the salivary flow rate in T1D was less than healthy subjects and T2D and CRP was found positive (6 mg/L) in 36% and 56% of patients with T1D and T2D, respectively. Saliva CRP was found to be related to the anthropometric measurement, blood pressure, and glycemic control.
We conclude that saliva CRP may be used as a biomarker for metabolic syndrome and its value is obvious in T2D rather than in T1D.
人类C反应蛋白（CRP）已被用于冠状动脉事件的风险评估。人类唾液反映身体的健康状况，且具有非侵入性、易于收集的特点，对于第三世界国家以及大规模患者筛查而言是理想选择。
本研究旨在考虑代谢综合征诊断标准的情况下，对糖尿病（1型和2型）患者的唾液CRP进行定性筛查。
糖尿病中心，前瞻性研究。
从糖尿病中心招募了50名2型糖尿病（T2D）患者、25名1型糖尿病（T1D）患者和25名健康受试者。对每位患者进行临床评估，并测定人体测量指标、血糖状态和血脂谱。测定刺激唾液流速和唾液CRP。
所有计算分析均使用适用于Windows的Excel 2003程序进行。
结果显示，T1D患者的唾液流速低于健康受试者和T2D患者，并且在T1D和T2D患者中，分别有36%和56%的患者CRP呈阳性（≥6 mg/L）。发现唾液CRP与人体测量指标、血压和血糖控制有关。
我们得出结论，唾液CRP可作为代谢综合征的生物标志物，其在T2D中的价值比在T1D中更明显。
