Goodman M A, McMaster J H, Drash A L, Diamond P E, Kappakas G S, Scranton P E
Cancer. 1978 Aug;42(2):603-10. doi: 10.1002/1097-0142(197808)42:2<603::aid-cncr2820420229>3.0.co;2-6.
Eighteen patients with primary osteosarcoma were studied for abnormal endocrinologic functions. Oral glucose tolerance tests revealed abnormal glucose, insulin, or growth hormone response curves in 78% of the study population. Elevated somatomedin values were noted in 72% of the patients tested. No significant deviations were observed in serum cortisol, estradiol, testosterone, follicle stimulating hormone, and luteinizing hormone levels. Likewise, lipid screening and 24 hour 17-hydroxy and 17-keto steroid excretion levels were normal. Statistically these derangements were unrelated, leading to the hypothesis that some additional factor or factors are present and responsible for the abnormalities noted. These deviations, found in association with primary osteosarcoma, constitute a new "paraneoplastic syndrome."
对18例原发性骨肉瘤患者进行了内分泌功能异常的研究。口服葡萄糖耐量试验显示，78%的研究对象存在葡萄糖、胰岛素或生长激素反应曲线异常。72%接受检测的患者生长介素值升高。血清皮质醇、雌二醇、睾酮、促卵泡激素和促黄体生成素水平未观察到明显偏差。同样，血脂筛查以及24小时17-羟类固醇和17-酮类固醇排泄水平均正常。从统计学角度来看，这些紊乱并无关联，由此提出假说，即存在某种或某些其他因素导致了所观察到的异常情况。这些与原发性骨肉瘤相关的偏差构成了一种新的“副肿瘤综合征”。
