McMaster J H, Scranton P E, Drash A L
Clin Orthop Relat Res. 1975 Jan-Feb(106):366-76. doi: 10.1097/00003086-197501000-00049.
The association between osteosarcoma and growth, including altered carbohydrate metabolism has been investigated in 5 osteosarcoma patients. Serum from an adolescent osteosarcoma patient has been noted to consistently enhance 3-H-thymidine uptake in cultured chondrocytes and tumor cells. Females survive osteosarcoma more frequently than males. In vitro serum-enhanced proliferation of osteosarcoma cells is suppressed by estradiol.
已对5例骨肉瘤患者研究了骨肉瘤与生长之间的关联，包括碳水化合物代谢改变。据观察，一名青少年骨肉瘤患者的血清可持续增强培养的软骨细胞和肿瘤细胞对3 - H - 胸腺嘧啶核苷的摄取。女性骨肉瘤患者的生存率高于男性。雌二醇可抑制体外血清增强的骨肉瘤细胞增殖。
