Adamson U, Broström L A, Efendić S, Hall K
Acta Endocrinol (Copenh). 1980 Aug;94(4):517-22. doi: 10.1530/acta.0.0940517.
Intravenous glucose tolerance, insulin response to glucose, the sensitivity of the periphery to insulin as well as growth hormone and somatomedin levels were determined in osteosarcoma patients and control subjects matched by age, sex, weight an length. The insulin response to glucose and the peripheral sensitivity to insulin were evaluated by using the individual blood glucose and plasma insulin curves for parameter identification in a mathematical model. The mean glucose tolerance was significantly decreased in the patients, most likely due to decreased peripheral insulin sensitivity. Plasma growth hormone levels were normal in all patients which was also the case with somatomedin levels determined by both radioreceptor- and radioimmunoassay.
测定了骨肉瘤患者以及按年龄、性别、体重和身高匹配的对照受试者的静脉葡萄糖耐量、胰岛素对葡萄糖的反应、外周对胰岛素的敏感性以及生长激素和生长调节素水平。通过使用个体血糖和血浆胰岛素曲线在数学模型中进行参数识别，评估胰岛素对葡萄糖的反应和外周对胰岛素的敏感性。患者的平均葡萄糖耐量显著降低，很可能是由于外周胰岛素敏感性降低所致。所有患者的血浆生长激素水平均正常，通过放射受体法和放射免疫法测定的生长调节素水平也是如此。
