Dai Chao, Dong Qing, Lu Qi, Liu Fang T, Zhu Zheng M
Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
Department of Radiotherapy, Jiangxi Cancer Hospital, Nanchang, China.
Minerva Chir. 2017 Feb;72(1):81-88. doi: 10.23736/S0026-4733.16.07198-4. Epub 2016 Oct 12.
Many studies recently suggested that Zinc-finger protein X-linked (ZFX) acted as a novel oncoprotein in various malignancies. It was frequently overexpressed in cancerous tissues and the high expression of ZFX may have important clinical value. This meta-analysis aims to investigate the prognostic value of ZFX as a biomarker of solid cancers.
We search for multiple databases, including Pubmed, Springer, Web of Science, CNKI from 1996 to Sep. 1, 2016. Eligible articles were collected to explore the association between the expression levels of ZFX and overall survival (OS).
There were totally 933 cancer patients from eight studies. The pooled results indicated that cancer patients with high ZFX expression have shorter overall survival times (HR=2.26, 95%CI:1.77-2.75, P=0.000) than those with low ZFX expression. Statistical significance was also observed in subgroup meta-analysis stratified in the sampling object and cancer type.
High expression of ZFX correlated with poor clinical outcome, ZFX might be sever as a potential prognostic biomarker in various cancers, especially for colorectal cancer.
最近许多研究表明，X连锁锌指蛋白（ZFX）在多种恶性肿瘤中作为一种新型癌蛋白发挥作用。它在癌组织中经常过度表达，ZFX的高表达可能具有重要的临床价值。这项荟萃分析旨在研究ZFX作为实体癌生物标志物的预后价值。
我们检索了多个数据库，包括1996年至2016年9月1日的PubMed、Springer、Web of Science、中国知网。收集符合条件的文章以探讨ZFX表达水平与总生存期（OS）之间的关联。
八项研究共有933例癌症患者。汇总结果表明，ZFX高表达的癌症患者总生存时间（HR=2.26，95%CI：1.77-2.75，P=0.000）比ZFX低表达的患者短。在按抽样对象和癌症类型分层的亚组荟萃分析中也观察到统计学意义。
ZFX的高表达与不良临床结局相关，ZFX可能作为各种癌症，尤其是结直肠癌的潜在预后生物标志物。
