消化系统癌症中 KLF4 降低的预后价值：来自 17 项研究的荟萃分析。
The Prognostic Value of Decreased KLF4 in Digestive System Cancers: A Meta-Analysis from 17 Studies.
机构信息
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
出版信息
Dis Markers. 2017;2017:3064246. doi: 10.1155/2017/3064246. Epub 2017 Sep 14.
BACKGROUND
The prognostic value of loss of Krüppel-like factor 4 (KLF4) expression in digestive system cancers has not reached a consensus. This study aimed for a comprehensive investigation of the internal associations between KLF4 expression loss and prognostic implications in patients with digestive system cancers.
METHODS
We searched for all relevant literatures in the electronic databases until February 1, 2017. The degree of association between KLF4 and prognosis was evaluated by pooled hazard ratios (HRs) as well as relevant 95% confidence intervals (95% CIs).
RESULTS
Seventeen eligible studies with 2118 patients revealed that loss of KLF4 expression was connected with poor prognosis, with the pooled HRs of 1.61 (95% CI: 1.17-2.20, = 0.003) for the overall survival (OS) and 1.99 (95% CI: 1.12-3.52, = 0.001) for the disease-free survival (DFS)/recurrence-free survival (RFS)/metastasis-free survival (MFS). Additionally, loss of KLF4 expression was also related to a worse disease-special survival (DSS) yielding a pooled HR of 1.73 (95% CI: 1.08-2.77, = 0.022).
CONCLUSION
Our findings suggest that loss of KLF4 expression is correlated with a bad outcome in most digestive system cancers, apart from esophagus squamous cell carcinoma (ESCC).
背景
Krüppel 样因子 4（KLF4）表达缺失在消化系统癌症中的预后价值尚未达成共识。本研究旨在全面探讨消化系统癌症患者中 KLF4 表达缺失与预后之间的内在关联。
方法
我们在电子数据库中搜索了截至 2017 年 2 月 1 日的所有相关文献。通过合并危险比（HRs）及其相关 95%置信区间（95%CI）评估 KLF4 与预后之间的关联程度。
结果
纳入的 17 项研究共包含 2118 例患者，结果显示 KLF4 表达缺失与预后不良相关，总生存（OS）的合并 HR 为 1.61（95%CI：1.17-2.20， = 0.003），无病生存（DFS）/无复发生存（RFS）/无转移生存（MFS）的合并 HR 为 1.99（95%CI：1.12-3.52， = 0.001）。此外，KLF4 表达缺失与疾病特异性生存（DSS）较差也相关，合并 HR 为 1.73（95%CI：1.08-2.77， = 0.022）。
结论
我们的研究结果表明，除食管鳞癌（ESCC）外，KLF4 表达缺失与大多数消化系统癌症的不良结局相关。
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