Simitchev S
Vutr Boles. 1989;28(3):33-7.
446 patients with an active peptic ulcer were examined. In 81.2% of them gastroesophageal reflux was found. In 220 patients the changes in the esophageal mucosa were studied morphologically. The patients were classified into groups according to their age and the duration of the disease. In 70.3% of the patients with a history of peptic ulcer over 15 years a reflux esophagitis was found and in 34.5% of the patients it was well expressed while in only 39% of the patients with a 5 year history of the disease a reflux esophagitis was found histologically and it was well expressed in 8.1% of them. Gastroesophageal reflux and reflux esophagitis are more frequent in patients over 40 years of age and in these patients the more severe forms prevail. The longer is the duration of the disease the greater is the number of cases with well expressed destructive changes.
对446例活动性消化性溃疡患者进行了检查。其中81.2%发现有胃食管反流。对220例患者的食管黏膜变化进行了形态学研究。根据患者年龄和病程将其分组。有超过15年消化性溃疡病史的患者中，70.3%发现有反流性食管炎，其中34.5%表现明显；而在病程为5年的患者中，仅39%经组织学检查发现有反流性食管炎，其中8.1%表现明显。胃食管反流和反流性食管炎在40岁以上患者中更为常见，且在这些患者中更严重的形式占主导。病程越长，有明显破坏性变化的病例数就越多。
