Enck P, Holtkötter B, Whitehead W E, Schuster M M, Wienbeck M
Abteilung für Gastroenterologie, Heinrich-Heine-Universität Düsseldorf.
Z Gastroenterol. 1989 Jul;27(7):357-61.
Recent investigations of pathogenesis of the irritable bowel syndrome (IBS) either suggested psychopathology as the cause of bowel symptoms or proposed abnormalities in colonic motor and myoelectrical activity. Therefore, we prospectively compared clinical symptoms, personality traits, subjective stress reports, and motor and myoelectrical activity of the sigmoid colon and rectum in patients with IBS, patients with lactose malabsorption (LMA) who had not consulted a doctor for bowel complaints, and normal subjects. It could be shown that neither colonic activity nor stress distinguished patients with IBS from those with LMA. Patients with IBS exhibited significantly more clinical symptoms and psychopathology than patients with LMA and normal subjects. These findings suggest that psychopathology does not cause the symptoms or results from bowel dysfunctions but determines who will consult a doctor for bowel complaints.
近期对肠易激综合征（IBS）发病机制的研究，要么认为精神病理学是肠道症状的病因，要么提出结肠运动和肌电活动存在异常。因此，我们前瞻性地比较了IBS患者、因肠道不适但未就医的乳糖吸收不良（LMA）患者以及正常受试者的临床症状、人格特质、主观压力报告，以及乙状结肠和直肠的运动和肌电活动。结果表明，结肠活动和压力均无法区分IBS患者与LMA患者。与LMA患者和正常受试者相比，IBS患者表现出明显更多的临床症状和精神病理学特征。这些发现表明，精神病理学并非肠道功能障碍导致的症状或结果，而是决定了谁会因肠道不适而就医。
