Kestin M, Clifton P M, Rouse I L, Nestel P J
CSIRO Division of Human Nutrition, Adelaide, Australia.
Am J Clin Nutr. 1989 Sep;50(3):528-32. doi: 10.1093/ajcn/50.3.528.
A double-blind, cross-over study of the effects of adding cholesterol to the diet, equal to about two egg yolks daily, was carried out in 25 men with an average plasma cholesterol of 5.3 mmol/L. There were no significant elevations in the mean plasma concentrations of cholesterol, low-density-lipoprotein cholesterol, or apolipoprotein B. The absence of an effect was seen against two background diets, one high in saturated fatty acids and the other modified in fat content and in fatty acid composition. Although the mean high-density-lipoprotein (HDL) cholesterol concentration did not change, the proportion of HDL2 particles (radius greater than 4.4 nm) increased significantly, especially in subjects who did not show a rise in plasma cholesterol; this may represent a means of clearing dietary cholesterol. The results suggest that reducing dietary cholesterol might be emphasized for hypercholesterolemic subjects rather than for the population generally.
对25名平均血浆胆固醇水平为5.3毫摩尔/升的男性进行了一项双盲交叉研究，研究在饮食中添加相当于每天约两个蛋黄的胆固醇的影响。血浆胆固醇、低密度脂蛋白胆固醇或载脂蛋白B的平均血浆浓度均无显著升高。在两种背景饮食下均未观察到影响，一种是富含饱和脂肪酸的饮食，另一种是脂肪含量和脂肪酸组成经过改良的饮食。虽然平均高密度脂蛋白（HDL）胆固醇浓度没有变化，但HDL2颗粒（半径大于4.4纳米）的比例显著增加，尤其是在血浆胆固醇没有升高的受试者中；这可能是清除膳食胆固醇的一种方式。结果表明，对于高胆固醇血症患者而非一般人群，可能更应强调降低膳食胆固醇。
