Ma Chengquan, Zhou Yaguang, Zhou Sufen, Zhao Kun, Lu Bingxin, Sun Erlin
Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Department of Operation Room, The Second Hospital of Tianjin Medical University, Tianjin, China.
Oncotarget. 2017 Feb 14;8(7):12355-12363. doi: 10.18632/oncotarget.12563.
High levels of peripheral plasma fibrinogen have recently been revealed that related to poor clinical prognosis in various types of malignant tumors. The purpose of this research was to identify the prognostic significance of the preoperative peripheral serum fibrinogen level in patients with penile cell carcinoma.
This retrospective research included 72 penile cancer patients with date about their serum fibrinogen value before surgery who undergone either partial or radical penectomy at The 2nd Hospital of Tianjin Medical University between January 2002 to January 2012. They had a mean follow-up of 30.8 months. To determine the factors that were significant in predicting a patient's prognosis, univariate and multivariate analyses were performed according to the Cox proportional hazards regression model.
The 5-year cancer specific survival (CSS) rate was 62.4% of patients with preoperative fibrinogen levels below 340 mg/dl and 41.9% for those with higher levels (p = 0.001). Multivariate analysis revealed that the pathological T stage (p < 0.001), tumor grade (p = 0.036), postoperative chemotherapy (p = 0.041), nodal metastasis(p < 0.001), pathological type (p < 0.001) and fibrinogen (p = 0.023) were independent prognostic factors for survival. Patients with low fibrinogen level (<340mg/dl) had significantly longer CSS and the different survival rate were defined using the log-rank test.
The high preoperative peripheral serum fibrinogen level was related to poor survival in penile cancer patients. Fibrinogen may serve as a powerful predictor of CSS in penile cancer patients.
近期研究发现，外周血血浆纤维蛋白原水平升高与多种恶性肿瘤的不良临床预后相关。本研究旨在确定术前外周血清纤维蛋白原水平对阴茎癌患者的预后意义。
本回顾性研究纳入了72例阴茎癌患者，这些患者于2002年1月至2012年1月在天津医科大学第二医院接受了部分或根治性阴茎切除术，术前均有血清纤维蛋白原值。他们的平均随访时间为30.8个月。根据Cox比例风险回归模型进行单因素和多因素分析，以确定对患者预后有显著影响的因素。
术前纤维蛋白原水平低于340mg/dl的患者5年癌症特异性生存率（CSS）为62.4%，而水平较高的患者为41.9%（p = 0.001）。多因素分析显示，病理T分期（p < 0.001）、肿瘤分级（p = 0.036）、术后化疗（p = 0.041）、淋巴结转移（p < 0.001）、病理类型（p < 0.001）和纤维蛋白原（p = 0.023）是生存的独立预后因素。纤维蛋白原水平低（<340mg/dl）的患者CSS显著更长，不同生存率采用对数秩检验确定。
术前外周血清纤维蛋白原水平高与阴茎癌患者生存率低相关。纤维蛋白原可能是阴茎癌患者CSS的有力预测指标。
