Ahmad Nisar, Fazal Hina, Ayaz Muhammad, Abbasi Bilal Haider, Mohammad Ijaz, Fazal Lubna
Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan ; Nuclear Institute for Food and Agriculture (NIFA) Tarnab, Peshawar 25000, Pakistan.
Asian Pac J Trop Biomed. 2011 Aug;1(4):330-3. doi: 10.1016/S2221-1691(11)60055-5.
The main objective of the current study is to investigate the potential of Carica papaya leaves extracts against Dengue fever in 45 year old patient bitten by carrier mosquitoes. For the treatment of Dengue fever the extract was prepared in water. 25 mL of aqueous extract of C. papaya leaves was administered to patient infected with Dengue fever twice daily i.e. morning and evening for five consecutive days. Before the extract administration the blood samples from patient were analyzed. Platelets count (PLT), White Blood Cells (WBC) and Neutrophils (NEUT) decreased from 176×10(3)/µL, 8.10×10(3)/µL, 84.0% to 55×10(3)/µL, 3.7×10(3)/µL and 46.0%. Subsequently, the blood samples were rechecked after the administration of leaves extract. It was observed that the PLT count increased from 55×10(3)/µL to 168×10(3)/µL, WBC from 3.7×10(3)/µL to 7.7×10(3)/µL and NEUT from 46.0% to 78.3%. From the patient feelings and blood reports it showed that Carica papaya leaves aqueous extract exhibited potential activity against Dengue fever. Furthermore, the different parts of this valuable specie can be further used as a strong natural candidate against viral diseases.
本研究的主要目的是调查番木瓜叶提取物对一名45岁被携带登革热病毒的蚊子叮咬的患者治疗登革热的潜力。为了治疗登革热，提取物用水配制。将25毫升番木瓜叶水提取物给予感染登革热的患者，每天两次，即早晚各一次，连续五天。在给予提取物之前，对患者的血样进行了分析。血小板计数（PLT）、白细胞（WBC）和中性粒细胞（NEUT）从176×10³/微升、8.10×10³/微升、84.0%降至55×10³/微升、3.7×10³/微升和46.0%。随后，在给予叶提取物后重新检查血样。观察到PLT计数从55×10³/微升增加到168×10³/微升，WBC从3.7×10³/微升增加到7.7×10³/微升，NEUT从46.0%增加到78.3%。从患者的感受和血液报告来看，番木瓜叶水提取物对登革热表现出潜在的活性。此外，这种珍贵物种的不同部位可进一步用作对抗病毒性疾病的强大天然候选物。
