Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, 331 Biomedical Research Building II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Medical Research, Philadelphia Corporal Michael J. Crescenz VA Medical Center (CMC VAMC), A424, University and Woodland Avenue, Philadelphia, PA 19104, USA; Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Clin Liver Dis. 2016 Nov;20(4):629-644. doi: 10.1016/j.cld.2016.06.001. Epub 2016 Aug 12.
Hepatitis B virus (HBV) infection is a major global health challenge. HBV can cause significant morbidity and mortality by establishing acute and chronic hepatitis. Approximately 250 million people worldwide are chronically infected, and more than 2 billion people have been exposed to HBV. Since the discovery of HBV, the advances in our understanding of HBV virology and immunology have translated into effective vaccines and therapies for HBV infection. Although current therapies successfully suppress viral replication but rarely succeed in viral eradication, recent discoveries in HBV virology and immunology provide exciting rationales for novel treatment strategies aiming at HBV cure.
乙型肝炎病毒 (HBV) 感染是一个全球性的健康挑战。HBV 可通过引发急性和慢性肝炎导致严重的发病率和死亡率。全世界约有 2.5 亿人慢性感染 HBV，超过 20 亿人曾接触过 HBV。自 HBV 被发现以来，我们对 HBV 病毒学和免疫学的理解的进步已经转化为有效的 HBV 感染疫苗和治疗方法。虽然目前的治疗方法可以成功抑制病毒复制，但很少能成功清除病毒，HBV 病毒学和免疫学的最新发现为旨在实现 HBV 治愈的新型治疗策略提供了令人兴奋的理由。
