乙型肝炎和丙型肝炎病毒及宿主在肝细胞癌发展中的多重作用。
Multiple Roles for Hepatitis B and C Viruses and the Host in the Development of Hepatocellular Carcinoma.
机构信息
Gastroenterology Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
The Corporal Michael J. Crescenz VA Medical Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
出版信息
Hepatology. 2021 Jan;73 Suppl 1(Suppl 1):27-37. doi: 10.1002/hep.31481. Epub 2020 Nov 7.
Abstract
Chronic hepatitis B and C viral infections are major risk factors for hepatocellular carcinoma (HCC) in the United States and worldwide. Direct and indirect mechanisms of viral infection lead to the development of HCC. Chronic viral infection leads to inflammation and liver damage, culminating in cirrhosis, the penultimate step in the progression toward HCC. Host, viral, and environmental factors likely interact to promote oncogenesis. Clinical considerations include recommendations for screening for HCC in persons at risk, treatment with antivirals, and an emerging role for immunotherapy in HCC. We pose unanswered questions regarding HCC susceptibility and pathogenesis in the setting of chronic hepatitis B and C.
摘要
慢性乙型肝炎和丙型肝炎病毒感染是美国和全球肝细胞癌（HCC）的主要危险因素。病毒感染的直接和间接机制导致 HCC 的发生。慢性病毒感染导致炎症和肝损伤，最终导致肝硬化，这是 HCC 进展的倒数第二步。宿主、病毒和环境因素可能相互作用以促进癌变。临床考虑因素包括对高危人群进行 HCC 筛查的建议、抗病毒治疗以及免疫疗法在 HCC 中的新作用。我们对慢性乙型肝炎和丙型肝炎背景下的 HCC 易感性和发病机制提出了尚未解决的问题。
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本文引用的文献
1
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N Engl J Med. 2020 May 14;382(20):1894-1905. doi: 10.1056/NEJMoa1915745.
2
Association of Aspirin with Hepatocellular Carcinoma and Liver-Related Mortality.阿司匹林与肝细胞癌及肝脏相关死亡率的关联。
N Engl J Med. 2020 Mar 12;382(11):1018-1028. doi: 10.1056/NEJMoa1912035.
3
The repertoire of mutational signatures in human cancer.人类癌症中的突变特征谱。
Nature. 2020 Feb;578(7793):94-101. doi: 10.1038/s41586-020-1943-3. Epub 2020 Feb 5.
4
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Gastroenterology. 2020 Jan;158(1):42-44. doi: 10.1053/j.gastro.2019.11.007. Epub 2019 Nov 7.
5
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Nat Immunol. 2019 Dec;20(12):1656-1667. doi: 10.1038/s41590-019-0511-1. Epub 2019 Oct 21.
6
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7
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