The partial pressure of isoflurane or halothane does not affect their solubility in rabbit blood or brain or human brain: inhaled anesthetics obey Henry's Law.

We tested the possibility that the solubility of halothane or isoflurane in rabbit blood or human or rabbit brain does not obey Henry's Law. We measured the blood/gas and brain/gas partition coefficients for both anesthetics at approximately 1 MAC and at 0.01 MAC at 37 degrees C. The partition coefficients determined at the high vs low partial pressures did not differ. We conclude that the solution of isoflurane and halothane in blood and brain obeys Henry's Law.