Müller M, Tisch M, Maier H, Löwenheim H
Universitätsklinik für Hals-Nasen-Ohren-Heilkunde, Medizinischer Campus Universität Oldenburg, Oldenburg, Deutschland.
Universitäts-Hals-Nasen-Ohren-Klinik, Universität Tübingen, Elfriede-Aulhorn-Str. 5, 72076, Tübingen, Deutschland.
HNO. 2016 Nov;64(11):831-840. doi: 10.1007/s00106-016-0256-1.
High-intensity noise exposure from impulse and blast noise events often leads to acute hearing loss and may cause irreversible permanent hearing loss as a long-term consequence. Here, a treatment regime was developed to limit permanent damage based on a preclinical animal model of acute noise trauma.
To develop clinical trials for the treatment of acute noise traumas using approved drugs. The otoprotective potential of glucocorticoids applied locally to the inner ear was examined.
A series of experiments with different impulse noise exposures was performed. Permanent hearing loss and hair cell density were assessed 14 days after exposure. Hearing and hair cell preservation were investigated as a function of glucocorticoid dose.
After impulse noise exposure, local application of high-dose prednisolone (25 mg/ml) or methylprednisolone (12.5 mg/ml) to the round window of the cochlea resulted in a statistically significant reduction in hearing loss compared to the control group.
Local application of high doses of the drugs to the round window of the cochlea appears to be an effective treatment for acute noise trauma.
脉冲和爆炸噪声事件产生的高强度噪声暴露常常导致急性听力损失，并可能作为长期后果造成不可逆的永久性听力损失。在此，基于急性噪声创伤的临床前动物模型，开发了一种治疗方案以限制永久性损伤。
使用已批准的药物开展治疗急性噪声创伤的临床试验。研究了局部应用于内耳的糖皮质激素的耳保护潜力。
进行了一系列不同脉冲噪声暴露的实验。在暴露后14天评估永久性听力损失和毛细胞密度。研究了听力和毛细胞保存情况与糖皮质激素剂量的关系。
脉冲噪声暴露后，与对照组相比，向耳蜗圆窗局部应用高剂量泼尼松龙（25mg/ml）或甲泼尼龙（12.5mg/ml）导致听力损失有统计学意义的降低。
向耳蜗圆窗局部应用高剂量药物似乎是治疗急性噪声创伤的有效方法。
