Thien Ady, See Angela An Qi, Ang Samantha Ya Lyn, Primalani Nishal Kishinchand, Lim Mervyn Jun Rui, Ng Yew Poh, King Nicolas Kon Kam
Department of Neurosurgery, National Neuroscience Institute, Singapore.
Department of Neurosurgery, National Neuroscience Institute, Singapore.
World Neurosurg. 2017 Jan;97:326-332. doi: 10.1016/j.wneu.2016.09.118. Epub 2016 Oct 12.
The prevalence of asymptomatic unruptured intracranial aneurysms (AUIA) in a Southeast Asian population has not been previously studied. Knowing the disease burden and population at risk can assist us in making informed decisions when managing AUIAs. We aimed to determine if the local prevalence of AUIAs differed from other populations in the published literature.
Magnetic resonance angiography radiology reports and images for 4572 patients between January 2013 and January 2014 were reviewed for AUIAs.
The overall prevalence of AUIAs was 3.5% (160/4572). It was significantly higher in women (4.5%) compared with men (2.6%) (P < 0.001). The mean aneurysm size was 3.2 ± 1.7 mm. Of the aneurysms, 88.5% (146/165) measured less than 5 mm, 9.7% (16/165) measured 5-9 mm, and 1.8% (3/165) measured more than 9 mm. Most of the aneurysms were located in the cavernous segment (72/165, 43.6%) and ophthalmic segment (34/165, 20.6%) of the internal carotid artery, followed by the middle cerebral artery (16/165, 9.7%). The posterior circulation contributed 9.1% (15/165) of the AUIAs. During the study period, 1 aneurysm ruptured and the rest of the aneurysms did not show any growth.
In this large cohort of a Southeast Asian population, the prevalence of AUIA was 3.5%. Most of the AUIAs were less than 5 mm and did not require intervention at time of discovery and did not progress within the year of follow-up.
此前尚未对东南亚人群中无症状未破裂颅内动脉瘤（AUIA）的患病率进行研究。了解疾病负担和高危人群有助于我们在管理AUIA时做出明智决策。我们旨在确定AUIA的当地患病率是否与已发表文献中的其他人群不同。
回顾了2013年1月至2014年1月期间4572例患者的磁共振血管造影放射学报告和图像，以筛查AUIA。
AUIA的总体患病率为3.5%（160/4572）。女性患病率（4.5%）显著高于男性（2.6%）（P<0.001）。动脉瘤平均大小为3.2±1.7mm。在动脉瘤中，88.5%（146/165）直径小于5mm，9.7%（16/165）直径为5-9mm，1.8%（3/165）直径大于9mm。大多数动脉瘤位于颈内动脉海绵窦段（72/165，43.6%）和眼段（34/165，20.6%），其次是大脑中动脉（16/165，9.7%）。后循环动脉瘤占AUIA的9.1%（15/165）。在研究期间，1例动脉瘤破裂，其余动脉瘤未显示任何生长。
在这个东南亚人群的大型队列中，AUIA的患病率为3.5%。大多数AUIA直径小于5mm，发现时不需要干预，且在随访年内没有进展。
