Nakayama Tetsuo
Kitasato Institute for Life Sciences, Laboratory of Viral Infection I, Minato-ku Shirokane 5-9-1, Tokyo 108-8641, Japan.
Vaccine. 2016 Nov 11;34(47):5815-5818. doi: 10.1016/j.vaccine.2016.08.051. Epub 2016 Oct 13.
The humoral and cellular immune responses of adaptive immunity are induced following immunization with effective vaccines. They induce functional cytokines and chemokines through the binding of vaccine components or adjuvants to innate immune receptors. Alum-adjuvanted vaccines induce local inflammatory nodules at injection sites, and the systemic and local production of the inflammatory cytokines, IL-1β, IL-6, and TNF-α, has been reported to occur three hours after vaccinations. Furthermore, G-CSF levels increase at injection sites. Neutrophils initially migrate and neutrophil extracellular traps (NETs) then develop, which stimulate damage-associated molecular patterns (DAMPs), inducing inflammatory cytokines production. Approximately 10-15% of recipients of simultaneous immunizations with multiple vaccines develop febrile reactions, and have higher G-CSF levels. Innate immune responses following vaccinations are discussed herein.
用有效的疫苗进行免疫接种后，可诱导适应性免疫的体液和细胞免疫反应。它们通过疫苗成分或佐剂与先天免疫受体的结合来诱导功能性细胞因子和趋化因子。明矾佐剂疫苗在注射部位诱导局部炎性结节，据报道，接种疫苗三小时后会出现炎性细胞因子IL-1β、IL-6和TNF-α的全身和局部产生。此外，注射部位的G-CSF水平会升高。中性粒细胞最初迁移，随后形成中性粒细胞胞外陷阱（NETs），刺激损伤相关分子模式（DAMPs），诱导炎性细胞因子的产生。同时接种多种疫苗的受种者中约有10-15%会出现发热反应，且G-CSF水平较高。本文讨论了接种疫苗后的先天免疫反应。
