Wilson W A, Armatis P E, Perez M C
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Ann Rheum Dis. 1989 Jul;48(7):600-4. doi: 10.1136/ard.48.7.600.
In a study of 66 patients with systemic lupus erythematosus (SLE) and 80 controls it was found that the presence of two deficiency (null) alleles of C4 had a significant effect on mean C4 concentrations in serum. In six controls who each had two C4 null alleles the mean C4 concentration in serum was 56% lower than in 43 controls without C4 null alleles; the nadir of the C4 concentration in four patients with SLE with two null alleles was also lower by a mean of 55% than in 32 patients who did not have null alleles. Reduced production of C4 allotypes in subjects with two null alleles may be an important determinant of total C4 concentration in patients with SLE. For optimal interpretation of C4 concentrations in SLE, C4 allotyping appears to be indicated, particularly to identify patients who have two null alleles of C4.
在一项针对66例系统性红斑狼疮（SLE）患者和80例对照者的研究中发现，C4的两个缺陷（无效）等位基因的存在对血清中C4的平均浓度有显著影响。在6名各自拥有两个C4无效等位基因的对照者中，血清中C4的平均浓度比43名没有C4无效等位基因的对照者低56%；4例拥有两个无效等位基因的SLE患者中C4浓度的最低点也比32例没有无效等位基因的患者平均低55%。拥有两个无效等位基因的受试者中C4同种异型的产生减少可能是SLE患者总C4浓度的一个重要决定因素。为了对SLE患者的C4浓度进行最佳解读，似乎有必要进行C4同种异型分型，特别是要识别出拥有两个C4无效等位基因的患者。
