Bagramian R A, Graves R C, Srivastava S
J Dent Res. 1977 Dec;56(12):1511-9. doi: 10.1177/00220345770560121801.
A series of preventive methods in combination have been used to reduce dental caries in children including dental health education, prophylaxes, pit and fissure sealants, topical application of fluoride and restorative care. Prophylaxes, sealant, and fluoride procedures are repeated every six months. Two-year results show reductions of occlusal caries increments of 74.3% for first graders and 77.1% for sixth graders. Sealant loss, as defined in this study, varied from 33% to 90% with the highest loss occurring in the newly erupted permanent molars during the first six months of the project. These high sealant loss rates are thought to be related to the age of the population which was designed to include children at the ages of peak eruption of permanent molar teeth (ages six and twelve). These teeth were often only minimally erupted and maintaining the dry field required for sealant retention was extremely difficult. However, in spite of these high rates of sealant loss, caries reduction on occlusal surfaces was highly significant in comparision to that of children who did not receive sealants.
一系列综合预防方法已被用于减少儿童龋齿，包括口腔健康教育、预防措施、窝沟封闭、氟化物局部应用和修复治疗。预防措施、窝沟封闭和氟化物治疗每六个月重复一次。两年的结果显示，一年级学生的咬合面龋齿增量减少了74.3%，六年级学生减少了77.1%。根据本研究的定义，窝沟封闭剂的脱落率在33%至90%之间，在项目的前六个月，新萌出的恒牙中窝沟封闭剂脱落率最高。这些高脱落率被认为与目标人群的年龄有关，该人群旨在纳入恒牙萌出高峰期（6岁和12岁）的儿童。这些牙齿通常萌出程度很小，保持窝沟封闭剂固位所需的干燥区域极其困难。然而，尽管窝沟封闭剂脱落率很高，但与未接受窝沟封闭的儿童相比，咬合面的龋齿减少仍然非常显著。
