Meng Fanbo, Wang Wei, Ma Jianghong, Lin Baisong
Department of Cardiology Department of Cardiac Surgery, China-Japan Union hospital of Jilin University, Changchun, China.
Medicine (Baltimore). 2016 Oct;95(40):e4810. doi: 10.1097/MD.0000000000004810.
Inconsistent findings have been reported on the association between the parathyroid hormone (PTH) level and risk of heart failure. We aimed to systematically evaluate the association between circulating level of PTH and risk of heart failure in the general population by conducting a meta-analysis. We made a comprehensive literature search in PubMed, Embase, VIP, CNKI, and Wanfang databases published until January 2016. Only prospective observational studies reporting the association between circulating level of PTH and risk of heart failure in the general population were selected. Pooled adjusted hazard ratio (HR) and corresponding 95% confidence intervals (CIs) were calculated for the highest versus lowest PTH category. Six studies with 25,207 participants identified. Higher circulating level of PTH was associated with an increased risk of heart failure (HR: 1.38; 95% CI 1.09-1.74) in a random effect model. Subgroup analyses revealed that the risk of heart failure was more pronounced among men (HR: 1.75; 95% CI 1.38-2.22) than in both genders. However, the risk increment was not statistically significant (HR: 1.12; 95% CI 0.76-1.66) in the middle-aged population. Higher PTH level is independently associated with an exacerbated risk of heart failure in the general population.
关于甲状旁腺激素（PTH）水平与心力衰竭风险之间的关联，已有不一致的研究结果报道。我们旨在通过进行一项荟萃分析，系统评估普通人群中PTH循环水平与心力衰竭风险之间的关联。我们在截至2016年1月发表的PubMed、Embase、维普、中国知网和万方数据库中进行了全面的文献检索。仅选择了报告普通人群中PTH循环水平与心力衰竭风险之间关联的前瞻性观察性研究。计算了最高与最低PTH类别之间的合并调整风险比（HR）及相应的95%置信区间（CI）。共纳入6项研究，涉及25207名参与者。在随机效应模型中，较高的PTH循环水平与心力衰竭风险增加相关（HR：1.38；95%CI 1.09 - 1.74）。亚组分析显示，男性心力衰竭风险增加更为明显（HR：1.75；95%CI 1.38 - 2.22）。然而，在中年人群中，风险增加无统计学意义（HR：1.12；95%CI 0.76 - 1.66）。较高的PTH水平与普通人群中心力衰竭风险加剧独立相关。
