Department of Clinical Laboratory, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310013, PR China.
Sci Rep. 2016 Oct 18;6:35388. doi: 10.1038/srep35388.
Herpangina, usually caused by coxsackie virus A, is prevalent in children spreading through the fecal-oral transmission and the respiratory droplets dissemination. Also, it is mostly asymptomatic and self-limiting. In our study, we found that large outbreak of herpangina in children occurred in the summer of 2015 in Hangzhou, China. From May 1th to August 31th, a total of 10 210 children were diagnosed with herpangina in Children's Hospital of Zhejiang University School of Medicine. 2 310 throat swabs were collected and tested for enterovirus detection by real-time RT-PCR, while 1 651 cases were positive with the rate of 71.5%. Based on VP1 gene or 5'UTR region sequences, Coxsackievirus A2, A4, A6, A10, B2, B4 and echovirus 30 were detected in these cases. More importantly, Coxsackievirus A2 may be the major subtype of enterovirus resulting in children with herpangina in hangzhou, China.
疱疹性咽峡炎通常由柯萨奇病毒 A 引起，在儿童中流行，通过粪-口途径和呼吸道飞沫传播。此外，它大多是无症状和自限性的。在我们的研究中，我们发现 2015 年夏季中国杭州发生了疱疹性咽峡炎的大规模暴发。2015 年 5 月 1 日至 8 月 31 日，浙江大学医学院附属儿童医院共诊断出 10210 例疱疹性咽峡炎患儿。采集了 2310 份咽拭子，通过实时 RT-PCR 进行肠道病毒检测，其中 1651 例呈阳性，阳性率为 71.5%。根据 VP1 基因或 5'UTR 区序列，在这些病例中检测到了柯萨奇病毒 A2、A4、A6、A10、B2、B4 和肠道病毒 30。更重要的是，柯萨奇病毒 A2 可能是导致中国杭州儿童患疱疹性咽峡炎的主要肠道病毒亚型。
