中国北京副中心地区疱疹性咽峡炎的分子流行病学：2021-2022 年监测研究。
Molecular epidemiology of herpangina in the subcenter of Beijing, China: a surveillance study during 2021-2022.
机构信息
Department of Laboratorial Science and Technology and Vaccine Research Center, School of Public Health, Peking University, Beijing, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
出版信息
Arch Virol. 2024 Nov 15;169(12):245. doi: 10.1007/s00705-024-06171-8.
In this study, we analyzed the dynamic molecular epidemiology of herpangina based on pharyngeal swabs and demographic data collected from children with herpangina monitored in Tongzhou district in China from January 2021 to December 2022. A total of 1022 herpangina cases were diagnosed. Out of 225 samples collected, 56.4% (127/225) were positive for non-polio enterovirus, with seven genotypes identified: coxsackievirus A4 (CV-A4), CV-A6, CV-A10, CV-A2, CV-A16, CV-B3, and CV-A8. The predominant genotypes associated with herpangina changed during and after the COVID-19 pandemic, with the predominant genotypes being CV-A4 and CV-A6 in 2021 and CV-A10 and CV-A6 in 2022.
在这项研究中，我们基于中国通州区 2021 年 1 月至 2022 年 12 月监测到的咽拭子和人口统计学数据，分析了疱疹性咽峡炎的动态分子流行病学。共诊断出 1022 例疱疹性咽峡炎病例。在采集的 225 份样本中，56.4%（127/225）为非脊灰肠道病毒阳性，鉴定出 7 种基因型：柯萨奇病毒 A4（CV-A4）、CV-A6、CV-A10、CV-A2、CV-A16、CV-B3 和 CV-A8。在 COVID-19 大流行期间和之后，与疱疹性咽峡炎相关的主要基因型发生了变化，2021 年主要基因型为 CV-A4 和 CV-A6，2022 年主要基因型为 CV-A10 和 CV-A6。
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