Weng Shihan, Zhu Rui, Wu Yuanyuan, Xia Ningshao, Xu Longfa, Cheng Tong
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, People's Republic of China.
National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University, Xiamen, People's Republic of China.
Emerg Microbes Infect. 2025 Dec;14(1):2441391. doi: 10.1080/22221751.2024.2441391. Epub 2024 Dec 22.
Group B Coxsackieviruses (CVBs) consist of six serotypes, CVB1 to CVB6, which can clinically affect the heart, brain, liver, pancreas and other organs, causing myocarditis, encephalitis, myelitis, pancreatitis, hand-foot-and-mouth disease (HFMD) and other diseases, and can even lead to death. CVBs are widespread globally and highly contagious. However, there are currently no approved CVB vaccines or effective treatments. The construction and optimization of animal models will aid in the in-depth understanding of CVB infections and its pathogenesis, providing essential tools for the exploration of vaccine development and antiviral therapies. This paper reviews the latest research progress and application prospects of CVB animal models.
B组柯萨奇病毒（CVBs）由6种血清型组成，即CVB1至CVB6，它们在临床上可影响心脏、大脑、肝脏、胰腺和其他器官，导致心肌炎、脑炎、脊髓炎、胰腺炎、手足口病（HFMD）等疾病，甚至可导致死亡。CVBs在全球广泛传播且具有高度传染性。然而，目前尚无获批的CVB疫苗或有效的治疗方法。动物模型的构建和优化将有助于深入了解CVB感染及其发病机制，为探索疫苗开发和抗病毒疗法提供重要工具。本文综述了CVB动物模型的最新研究进展和应用前景。
