水凝胶的合成方法……综述。
Methods of synthesis of hydrogels … A review.
作者信息
Akhtar Muhammad Faheem, Hanif Muhammad, Ranjha Nazar Muhammad
机构信息
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
出版信息
Saudi Pharm J. 2016 Sep;24(5):554-559. doi: 10.1016/j.jsps.2015.03.022. Epub 2015 Mar 21.
Abstract
Hydrogels are being investigated recently for the bioactive molecules (in particular pharmaceutical proteins) controlled release, such as matrices, and for the living cells encapsulation. Biodegradable nature of hydrogels has created much interest for drug delivery systems. The original three-dimensional structure disintegrates into nontoxic substances to ascertain an excellent biocompatibility of the gel. Chemical cross-linking is the highly resourceful method for the formation of hydrogels having an excellent mechanical strength. Cross-linkers used in hydrogel preparation should be extracted from the hydrogels before use due to their reported toxicity. Physically cross-linked methods for preparation of hydrogel are the alternate solution of cross-linker toxicity.
摘要
近年来，水凝胶因其可控制生物活性分子（尤其是药物蛋白）的释放（如作为基质）以及用于封装活细胞而受到研究。水凝胶的可生物降解特性使其在药物递送系统方面备受关注。其原始的三维结构会分解为无毒物质，从而确保凝胶具有出色的生物相容性。化学交联是形成具有出色机械强度的水凝胶的极为有效的方法。由于据报道具有毒性，水凝胶制备中使用的交联剂在使用前应从水凝胶中提取出来。物理交联制备水凝胶的方法是解决交联剂毒性问题的替代方案。
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