来自硬葡聚糖的新型水凝胶体系：合成与表征

Novel hydrogel system from scleroglucan: synthesis and characterization.

作者信息

Coviello T, Grassi M, Rambone G, Santucci E, Carafa M, Murtas E, Riccieri F M, Alhaique F

机构信息

Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università 'La Sapienza', P.le A.Moro 5, 00185, Rome, Italy.

出版信息

J Control Release. 1999 Aug 5;60(2-3):367-78. doi: 10.1016/s0168-3659(99)00091-7.

DOI:10.1016/s0168-3659(99)00091-7

PMID:10425341

Abstract

New hydrogels obtained by a crosslinking reaction between the polycarboxylated derivative of scleroglucan (sclerox) and 1, 6-hexanedibromide have been prepared and characterized. Different ratios between the alkane dihalide and sclerox yielded products with appreciably different properties. Water uptake by the hydrogel with a low degree of crosslinking was remarkably affected by ionic strength. The diffusion of a model molecule (theophylline) through the swelled crosslinked polymers was studied and the theoretical analysis leading to the calculation of permeability coefficients in different environmental conditions is reported. Tablets prepared with one of the new hydrogels behaved as swellable monolithic systems suitable for sustained drug release.

摘要

通过硬葡聚糖的聚羧化衍生物（硬葡聚糖x）与1,6 - 己二溴之间的交联反应获得的新型水凝胶已被制备并表征。烷二卤化物与硬葡聚糖x之间的不同比例产生了具有明显不同性质的产物。低交联度水凝胶的吸水率受到离子强度的显著影响。研究了模型分子（茶碱）在溶胀的交联聚合物中的扩散，并报道了在不同环境条件下导致渗透系数计算的理论分析。用一种新型水凝胶制备的片剂表现为适用于药物缓释的可溶胀整体系统。