Sautès-Fridman Catherine, Lawand Myriam, Giraldo Nicolas A, Kaplon Hélène, Germain Claire, Fridman Wolf Herman, Dieu-Nosjean Marie-Caroline
INSERM, UMR_S 1138, Team "Cancer, Immune Control and Escape", Cordeliers Research Center, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, University Paris Descartes, Paris, France; UMR_S 1138, Centre de Recherche des Cordeliers, Sorbonne University, UPMC University Paris 06, Paris, France.
Front Immunol. 2016 Oct 3;7:407. doi: 10.3389/fimmu.2016.00407. eCollection 2016.
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses. A correlation has been found between high densities of TLS and prolonged patient's survival in more than 10 different types of cancer. TLS can be regulated by the same set of chemokines and cytokines that orchestrate lymphoid organogenesis and by regulatory T cells. Thus, TLS offer a series of putative new targets that could be used to develop therapies aiming to increase the anti-tumor immune response.
三级淋巴结构（TLS）是异位淋巴聚集物，反映了炎症部位组织中发生的淋巴新生。它们在肿瘤中被检测到，在肿瘤中它们协调局部和全身的抗肿瘤反应。在10多种不同类型的癌症中，已发现TLS的高密度与患者生存期延长之间存在相关性。TLS可由一组协调淋巴器官发生的趋化因子和细胞因子以及调节性T细胞调节。因此，TLS提供了一系列可能的新靶点，可用于开发旨在增强抗肿瘤免疫反应的疗法。
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