氨氯地平用于治疗高血压：一种可有效改善血压及患者预后的一线药物。
Amlodipine in hypertension: a first-line agent with efficacy for improving blood pressure and patient outcomes.
作者信息
Fares Hassan, DiNicolantonio James J, O'Keefe James H, Lavie Carl J
机构信息
Department of Cardiovascular Diseases , John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine , New Orleans, Louisiana , USA.
Saint Luke's Mid America Heart Institute , Kansas City, Missouri , USA.
出版信息
Open Heart. 2016 Sep 28;3(2):e000473. doi: 10.1136/openhrt-2016-000473. eCollection 2016.
OBJECTIVES
Hypertension is well established as a major risk factor for cardiovascular disease. Although there is undeniable evidence to support the beneficial effects of antihypertensive therapy on morbidity and mortality, adequate blood pressure management still remains suboptimal. Research into the treatment of hypertension has produced a multitude of drug classes with different efficacy profiles. These agents include β-blockers, diuretics, ACE inhibitors, angiotensin receptor blockers and calcium channel blockers. One of the oldest groups of antihypertensives, the calcium channel blockers are a heterogeneous group of medications.
METHODS
This review paper will focus on amlodipine, a dihydropyridine calcium channel blockers, which has been widely used for 2 decades.
RESULTS
Amlodipine has good efficacy and safety, in addition to strong evidence from large randomised controlled trials for cardiovascular event reduction.
CONCLUSIONS
Amlodipine should be considered a first-line antihypertensive agent.
目的
高血压已被确认为心血管疾病的主要危险因素。尽管有不可否认的证据支持抗高血压治疗对发病率和死亡率的有益影响，但血压的充分管理仍不尽人意。对高血压治疗的研究产生了多种具有不同疗效的药物类别。这些药物包括β受体阻滞剂、利尿剂、血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂和钙通道阻滞剂。作为最古老的抗高血压药物类别之一，钙通道阻滞剂是一类异质性药物。
方法
本综述文章将聚焦于氨氯地平，一种已广泛使用20年的二氢吡啶类钙通道阻滞剂。
结果
氨氯地平具有良好的疗效和安全性，此外还有大型随机对照试验的有力证据表明其可减少心血管事件。
结论
氨氯地平应被视为一线抗高血压药物。
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