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Statins in patients with sepsis and ARDS: is it over? We are not sure.

作者信息

McAuley Danny, Charles Pierre-Emmanuel, Papazian Laurent

机构信息

Centre for Experimental Medicine, Queen's University of Belfast, Belfast, BT9 7AE, UK.

Regional Intensive Care Unit, The Royal Hospitals, Grosvenor Road, Belfast, BT12 6BA, UK.

出版信息

Intensive Care Med. 2017 May;43(5):677-679. doi: 10.1007/s00134-016-4454-9. Epub 2016 Oct 17.

DOI:10.1007/s00134-016-4454-9
PMID:27752736
Abstract
摘要

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本文引用的文献

1
Incidence of Sepsis and Mortality With Prior Exposure of HMG-COA Reductase Inhibitors in a Surgical Intensive Care Population.外科重症监护人群中先前使用HMG - CoA还原酶抑制剂后的脓毒症发病率及死亡率
Shock. 2016 Jan;45(1):10-5. doi: 10.1097/SHK.0000000000000484.
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Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care.治疗效果异质性对重症监护随机试验报告与分析的影响
Am J Respir Crit Care Med. 2015 Nov 1;192(9):1045-51. doi: 10.1164/rccm.201411-2125CP.
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Statin therapy and mortality from sepsis: a meta-analysis of randomized trials.
新型冠状病毒肺炎患者 γδ T 淋巴细胞表型和功能的改变：他汀类药物的逆转作用。
Cells. 2022 Oct 31;11(21):3449. doi: 10.3390/cells11213449.
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Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis.奥曲肽对实验性脓毒症大鼠肺的短期保护作用。
Ulus Travma Acil Cerrahi Derg. 2022 Jan;28(1):8-14. doi: 10.14744/tjtes.2020.02589.
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Adjunctive therapies during veno-venous extracorporeal membrane oxygenation.静脉-静脉体外膜肺氧合期间的辅助治疗
J Thorac Dis. 2018 Mar;10(Suppl 5):S683-S691. doi: 10.21037/jtd.2017.10.08.
6
Linezolid and atorvastatin impact on pneumonia caused by Staphyloccocus aureus in rabbits with or without mechanical ventilation.利奈唑胺和阿托伐他汀对伴或不伴机械通气的兔金黄色葡萄球菌肺炎的影响。
PLoS One. 2017 Nov 17;12(11):e0187187. doi: 10.1371/journal.pone.0187187. eCollection 2017.
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Update of Sepsis in the Intensive Care Unit.《重症监护病房中的脓毒症更新》。
J Innate Immun. 2017;9(5):441-455. doi: 10.1159/000477419. Epub 2017 Jul 12.
8
Statin therapy for acute respiratory distress syndrome: an individual patient data meta-analysis of randomised clinical trials.他汀类药物治疗急性呼吸窘迫综合征：随机临床试验的个体患者数据荟萃分析。
Intensive Care Med. 2017 May;43(5):663-671. doi: 10.1007/s00134-016-4649-0. Epub 2016 Dec 21.
他汀类药物治疗与脓毒症死亡率：随机试验的荟萃分析。
Am J Med. 2015 Apr;128(4):410-7.e1. doi: 10.1016/j.amjmed.2014.10.057. Epub 2014 Dec 17.
4
Simvastatin in the acute respiratory distress syndrome.辛伐他汀治疗急性呼吸窘迫综合征。
N Engl J Med. 2014 Oct 30;371(18):1695-703. doi: 10.1056/NEJMoa1403285. Epub 2014 Sep 30.
5
Effect of the use of low and high potency statins and sepsis outcomes.低、高效力他汀类药物的使用对脓毒症结局的影响。
Intensive Care Med. 2014 Oct;40(10):1509-17. doi: 10.1007/s00134-014-3418-1. Epub 2014 Aug 5.
6
Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.急性呼吸窘迫综合征的亚表型：两项随机对照试验数据的潜在类别分析。
Lancet Respir Med. 2014 Aug;2(8):611-20. doi: 10.1016/S2213-2600(14)70097-9. Epub 2014 May 19.
7
Rosuvastatin for sepsis-associated acute respiratory distress syndrome.瑞舒伐他汀用于脓毒症相关急性呼吸窘迫综合征
N Engl J Med. 2014 Jun 5;370(23):2191-200. doi: 10.1056/NEJMoa1401520. Epub 2014 May 18.
8
Impact of prior statin therapy on the outcome of patients with suspected ventilator-associated pneumonia: an observational study.既往他汀类药物治疗对疑似呼吸机相关性肺炎患者预后的影响：一项观察性研究。
Crit Care. 2014 Apr 28;18(2):R83. doi: 10.1186/cc13845.
9
Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: a randomized clinical trial.他汀类药物治疗对呼吸机相关性肺炎患者死亡率的影响：一项随机临床试验。
JAMA. 2013 Oct 23;310(16):1692-700. doi: 10.1001/jama.2013.280031.
10
A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis.一项多中心随机临床试验，评估阿托伐他汀治疗重症监护病房严重脓毒症患者的疗效。
Am J Respir Crit Care Med. 2013 Apr 1;187(7):743-50. doi: 10.1164/rccm.201209-1718OC.