Warzecha Zygmunt, Sendur Paweł, Ceranowicz Piotr, Dembiński Marcin, Cieszkowski Jakub, Kuśnierz-Cabala Beata, Olszanecki Rafał, Tomaszewska Romana, Ambroży Tadeusz, Dembiński Artur
Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegórzecka St., 31-531 Cracow, Poland.
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Cracow, Poland.
Int J Mol Sci. 2016 Oct 12;17(10):1709. doi: 10.3390/ijms17101709.
Coagulation is recognized as a key player in inflammatory and autoimmune diseases. The aim of the current research was to examine the effect of pretreatment with acenocoumarol on the development of acute pancreatitis (AP) evoked by cerulein.
AP was induced in rats by cerulein administered intraperitoneally. Acenocoumarol (50, 100 or 150 µg/kg/dose/day) or saline were given once daily for seven days before AP induction.
In rats with AP, pretreatment with acenocoumarol administered at the dose of 50 or 100 µg/kg/dose/day improved pancreatic histology, reducing the degree of edema and inflammatory infiltration, and vacuolization of acinar cells. Moreover, pretreatment with acenocoumarol given at the dose of 50 or 100 µg/kg/dose/day reduced the AP-evoked increase in pancreatic weight, serum activity of amylase and lipase, and serum concentration of pro-inflammatory interleukin-1β, as well as ameliorated pancreatic DNA synthesis and pancreatic blood flow. In contrast, acenocoumarol given at the dose of 150 μg/kg/dose did not exhibit any protective effect against cerulein-induced pancreatitis.
Low doses of acenocoumarol, given before induction of AP by cerulein, inhibit the development of that inflammation.
凝血被认为是炎症和自身免疫性疾病中的关键因素。本研究的目的是检验醋硝香豆素预处理对由蛙皮素诱发的急性胰腺炎（AP）发展的影响。
通过腹腔注射蛙皮素在大鼠中诱导AP。在诱导AP前7天，每天一次给予醋硝香豆素（50、100或150μg/kg/剂量/天）或生理盐水。
在患有AP的大鼠中，以50或100μg/kg/剂量/天的剂量给予醋硝香豆素预处理改善了胰腺组织学，减轻了水肿程度、炎症浸润以及腺泡细胞的空泡化。此外，以50或100μg/kg/剂量/天的剂量给予醋硝香豆素预处理降低了AP诱发的胰腺重量增加、淀粉酶和脂肪酶的血清活性、促炎白细胞介素-1β的血清浓度，还改善了胰腺DNA合成和胰腺血流。相比之下，以150μg/kg/剂量给予的醋硝香豆素对蛙皮素诱导的胰腺炎未表现出任何保护作用。
在由蛙皮素诱导AP之前给予低剂量的醋硝香豆素可抑制该炎症的发展。
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