O'Boyle M, Amadeo M
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77550.
J Geriatr Psychiatry Neurol. 1989 Apr-Jun;2(2):83-6. doi: 10.1177/089198878900200205.
The suggestion that patients having depression with reversible dementia make more "don't know" responses to cognitive questions than do demented patients was tested. Inpatients were administered the Mini-Mental Status Examination (MMSE) on admission and shortly before discharge. Errors and "don't know" responses were recorded. Groups were defined as (1) demented (n = 20; diagnosis of dementia, entrance and exit MMSE less than 24) and (2) depressed with reversible dementia (DRD, n = 11; diagnosis of major depression, entrance MMSE less than 24, exit MMSE greater than 24, delta MMSE greater than 3). Groups differed significantly on MMSE scores and errors, with demented patients scoring lower and making more errors than the DRD group. Groups did not differ significantly in "don't know" responses. Comparisons between groups on sections of the MMSE showed that demented patients scored significantly lower and made more errors than DRD patients only on the orientation section of the MMSE. The results suggest that DRD patients do not make more "don't know" responses than demented patients; however, demented patients make more errors on orientation questions.
研究对患有可逆性痴呆的抑郁症患者比痴呆患者在认知问题上给出更多“不知道”回答这一观点进行了测试。对住院患者在入院时和即将出院前进行简易精神状态检查表（MMSE）测试。记录错误和“不知道”回答。分组如下：（1）痴呆组（n = 20；痴呆诊断，入院和出院时MMSE评分低于24）和（2）伴有可逆性痴呆的抑郁症组（DRD，n = 11；重度抑郁症诊断，入院时MMSE评分低于24，出院时MMSE评分高于24，MMSE评分变化大于3）。两组在MMSE评分和错误方面存在显著差异，痴呆患者得分更低且错误更多，比DRD组严重。两组在“不知道”回答方面无显著差异。MMSE各部分的组间比较显示，痴呆患者仅在MMSE的定向部分得分显著低于DRD患者且错误更多。结果表明，DRD患者在认知问题上给出的“不知道”回答并不比痴呆患者多；然而，痴呆患者在定向问题上错误更多。
