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美国家具工人的癌症及其他死亡率模式。

Cancer and other mortality patterns among United States furniture workers.

作者信息

Miller B A, Blair A E, Raynor H L, Stewart P A, Zahm S H, Fraumeni J F

机构信息

Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20892.

出版信息

Br J Ind Med. 1989 Aug;46(8):508-15. doi: 10.1136/oem.46.8.508.

DOI:10.1136/oem.46.8.508
PMID:2775670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1009819/
Abstract

Cause specific mortality was investigated among 36,622 members of a national furniture workers' union who were first employed in unionised shops between 1946 and 1962. Overall mortality for each race and sex group was less than expected when compared with United States death rates (white men SMR = 0.8, black men SMR = 0.7, white women SMR = 0.8, black women SMR = 0.5); however, raised risks were observed among white men employed in specific types of furniture industries and followed up for 20 or more years after first employment. Lymphatic and haematopoietic cancers were significantly raised (SMR = 1.8) among wood furniture workers followed up for at least 20 years due to excess deaths from leukaemia (SMR = 2.0) and non-Hodgkin's lymphoma (SMR = 2.0). Mortality from acute myeloid leukaemia was particularly high in this group (SMR = 4.7) based on six observed cases. Metal furniture workers followed up for at least 20 years experienced a significant excess of all cancers combined (SMR = 1.6), with non-significant increases in cancers of the lung, stomach, and colorectum. This group also had non-significant excesses of liver cirrhosis, arteriosclerotic heart disease, and cerebrovascular disease. Nasal cancer was not found to be significantly raised in this cohort, though the average follow up period may not have been sufficient to detect an excess risk for this uncommon tumour.

摘要

对全国家具工人工会的36622名成员进行了死因特异性死亡率调查,这些成员于1946年至1962年期间首次受雇于工会化的工厂。与美国死亡率相比,每个种族和性别人群的总体死亡率均低于预期(白人男性标准化死亡比(SMR)=0.8,黑人男性SMR = 0.7,白人女性SMR = 0.8,黑人女性SMR = 0.5);然而,在特定类型家具行业工作且首次就业后随访20年或更长时间的白人男性中观察到风险升高。在随访至少20年的木制家具工人中,淋巴和造血系统癌症显著升高(SMR = 1.8),这是由于白血病(SMR = 2.0)和非霍奇金淋巴瘤(SMR = 2.0)导致的死亡过多。基于6例观察病例,该组急性髓系白血病的死亡率特别高(SMR = 4.7)。随访至少20年的金属家具工人所有癌症合并发生率显著过高(SMR = 1.6),肺癌、胃癌和结直肠癌的发生率有非显著性增加。该组肝硬化、动脉硬化性心脏病和脑血管疾病的发生率也有非显著性过高。在该队列中未发现鼻咽癌显著升高,尽管平均随访期可能不足以检测到这种罕见肿瘤的额外风险。

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本文引用的文献

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Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study.恶性淋巴瘤与化学物质暴露,尤其是有机溶剂、氯酚和苯氧基酸:一项病例对照研究。
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Cancer incidence among painters and some allied trades.
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Cancer mortality among workers exposed to zinc chromate paints.接触铬酸锌涂料的工人中的癌症死亡率。
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A pilot study on respiratory and digestive tract cancer among woodworkers.一项针对木工呼吸道和消化道癌症的初步研究。
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Epidemiological study of socioeconomic factors and clinical findings in Hodgkin's disease, and reanalysis of previous data regarding chemical exposure.霍奇金淋巴瘤社会经济因素与临床发现的流行病学研究,以及既往化学物质暴露相关数据的重新分析。
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