Das Kaushik Deb, Ghosh Shubhamoy, Das Asim Kumar, Ghosh Aloke, Mondal Ramkumar, Banerjee Tanapa, Ali Seikh Sajid, Ali Seikh Swaif, Koley Munmun, Saha Subhranil
Department of Homoeopathic Pharmacy, Midnapore Homoeopathic Medical College and Hospital, Government of West Bengal, Paschim Medinipur, West Bengal, India.
Department of Pathology and Microbiology, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Government of West Bengal, Howrah, West Bengal, India.
J Intercult Ethnopharmacol. 2016 Jun 25;5(4):335-342. doi: 10.5455/jice.20160608030224. eCollection 2016 Sep-Dec.
Controversies and disagreement exist on conventional treatment strategies of hemorrhoids due to relapse, inefficacy, and complications. We intend to evaluate the role of individualized homeopathic treatment in hemorrhoids.
In this prospective, open, observational trial, hemorrhoids patients were treated using five standardized scales measuring complaints severity and anoscopic score. It was conducted at two homeopathic hospitals in India, during from mid-July 2014 to mid-July 2015. Patients were intervened as per individualized homeopathic principles and followed up every month up to 6 months.
Total 73 were screened, 52 enrolled, 38 completed, 14 dropped out. Intention to treat population (: = 52) was analyzed in the end. Statistically significant reductions of mean bleeding (month 3: -21.8, 95% confidence interval [CI]: -30.3, -13.3, : < 0.00001, d = 0.787; month 6: -25.5, 95% CI -35.4, -15.6, : < 0.00001, d = 0.775), pain (month 3: -21.3, 95% CI -28.6, -14.0, : < 0.00001, d = 0.851; month 6: -27.6, 95% CI -35.6, -19.6, : < 0.00001, d = 1.003), heaviness visual analog scales (VASs) (month 3: -8.1, 95% CI -13.9, -2.3, : = 0.008, d = 0.609; month 6: -12.1, 95% CI -19.1, -5.1, : = 0.001, d = 0.693), and anoscopic score (month 3: -0.4, 95% CI -0.6, -0.2, : < 0.0001, d = 0.760; month 6: -0.5, 95% CI -0.7, -0.3, : < 0.0001, d = 0.703) were achieved. Itching VASs reduced significantly only after 6 months (-8.1, 95% CI -14.6, -1.6, : = 0.017, d = 0.586). No significant lowering of discharge VASs was achieved after 3 and 6 months.
Under classical homeopathic treatment, hemorrhoids patients improved considerably in symptoms severity and anoscopic scores. However, being observational trial, our study cannot provide efficacy data. Controlled studies are required. Trial Reg. CTRI/2015/07/005958.
由于复发、无效及并发症等问题，痔疮的传统治疗策略存在争议和分歧。我们旨在评估个体化顺势疗法治疗痔疮的作用。
在这项前瞻性、开放性观察试验中，使用五个标准化量表来测量痔疮患者的症状严重程度和肛门镜检查评分。该试验于2014年7月中旬至2015年7月中旬在印度的两家顺势疗法医院进行。患者按照个体化顺势疗法原则进行干预，并每月随访直至6个月。
共筛查73例，52例入组，38例完成试验，14例退出。最终对意向性治疗人群（n = 52）进行分析。平均出血情况有统计学意义的降低（第3个月：-21.8，95%置信区间[CI]：-30.3，-13.3，P < 0.00001，d = 0.787；第6个月：-25.5，95% CI -35.4，-15.6，P < 0.00001，d = 0.775）、疼痛（第3个月：-21.3，95% CI -28.6，-14.0，P < 0.00001，d = 0.851；第6个月：-27.6，95% CI -35.6，-19.6，P < 0.00001，d = 1.003）、坠胀视觉模拟量表（VAS）评分（第3个月：-8.1，95% CI -13.9，-2.3，P = 0.008，d = 0.609；第6个月：-12.1，95% CI -19.1，-5.1，P = 0.001，d = 0.693）以及肛门镜检查评分（第3个月：-0.4，95% CI -0.6，-0.2，P < 0.0001，d = 0.760；第6个月：-0.5，95% CI -0.7，-0.3，P < 0.0001，d = 0.703）均得以实现。瘙痒VAS评分仅在6个月后显著降低（-8.1，95% CI -14.6，-1.6，P = 0.017，d = 0.586）。3个月和6个月后，分泌物VAS评分无显著降低。
在经典顺势疗法治疗下，痔疮患者的症状严重程度和肛门镜检查评分有显著改善。然而，由于本研究为观察性试验，无法提供疗效数据。需要进行对照研究。试验注册号：CTRI/2015/07/005958。
