Amber Kyle T, Panganiban Christine M, Korta Dorota, Feraudy Sebastien de, Kelly Kristen M, Grando Sergei A
Department of Dermatology, University of California Irvine, Irvine, California, USA.
Melanoma Res. 2017 Feb;27(1):65-67. doi: 10.1097/CMR.0000000000000307.
The association of bullous pemphigoid with melanoma remains controversial and poorly understood. Recent studies report the presence of the bullous pemphigoid antigen, BP180, in melanoma cells, yet not normal melanocytes, suggesting an underlying mechanism for cases of melanoma-associated bullous pemphigoid. We report on an 88-year-old woman who showed a temporal relationship between the development of bullous pemphigoid and melanoma. The patient did not receive programmed death ligand 1 inhibitor therapy and improved rapidly following complete excision of her melanoma, with clobetasol, doxycycline, and niacinamide. We review the literature on the relationship between bullous pemphigoid and melanoma, and propose a mechanism underlying a melanoma-associated bullous pemphigoid.
大疱性类天疱疮与黑色素瘤之间的关联仍存在争议且了解甚少。近期研究报告称，黑色素瘤细胞中存在大疱性类天疱疮抗原BP180，但正常黑素细胞中不存在，这提示了黑色素瘤相关大疱性类天疱疮病例的潜在机制。我们报告了一名88岁女性，其大疱性类天疱疮的发生与黑色素瘤之间存在时间关联。该患者未接受程序性死亡配体1抑制剂治疗，在黑色素瘤完全切除后，使用氯倍他索、强力霉素和烟酰胺，病情迅速好转。我们回顾了关于大疱性类天疱疮与黑色素瘤关系的文献，并提出了黑色素瘤相关大疱性类天疱疮的潜在机制。
