小鼠树突状细胞的功能。
Functions of Murine Dendritic Cells.
作者信息
Durai Vivek, Murphy Kenneth M
机构信息
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Immunity. 2016 Oct 18;45(4):719-736. doi: 10.1016/j.immuni.2016.10.010.
Abstract
Dendritic cells (DCs) play critical roles in activating innate immune cells and initiating adaptive immune responses. The functions of DCs were originally obscured by their overlap with other mononuclear phagocytes, but new mouse models have allowed for the selective ablation of subsets of DCs and have helped to identify their non-redundant roles in the immune system. These tools have elucidated the functions of DCs in host defense against pathogens, autoimmunity, and cancer. This review will describe the mouse models generated to interrogate the role of DCs and will discuss how their use has progressively clarified our understanding of the unique functions of DC subsets.
摘要
树突状细胞（DCs）在激活先天免疫细胞和启动适应性免疫反应中发挥着关键作用。DCs的功能最初因其与其他单核吞噬细胞的重叠而被掩盖，但新的小鼠模型已能够选择性地清除DCs亚群，并有助于确定它们在免疫系统中的非冗余作用。这些工具阐明了DCs在宿主抵御病原体、自身免疫和癌症中的功能。本综述将描述为探究DCs的作用而构建的小鼠模型，并讨论如何通过使用这些模型逐步加深我们对DC亚群独特功能的理解。
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