Rud N P, Reiman H M, Pritchard D J, Frassica F J, Smithson W A
Section of Surgical Pathology, Mayo Clinic, Rochester, Minnesota 55905.
Cancer. 1989 Oct 1;64(7):1548-53. doi: 10.1002/1097-0142(19891001)64:7<1548::aid-cncr2820640733>3.0.co;2-w.
Fifty patients at the Mayo Clinic (Rochester, MN) from 1935 to 1985 met the histologic criteria for extraosseous Ewing's sarcoma. Forty-two had soft tissue primaries without bony involvement and formed the basis for this retrospective study of the clinical behavior and management of extraosseous Ewing's sarcoma. There were 19 male and 23 female patients (mean age, 22 years). Metastases were documented in 30 of the patients, six at the time of presentation and 24 occurring up to 11 years later, most commonly to lungs or bone. Three patients were lost to follow-up. Sixteen of 35 patients (46%) had local recurrence. Overall survival was 15 of 39 (38.5%) at 5 years. Decreased survival was noted with pelvic tumors, incomplete resections, and presence of metastatic disease, whereas increased survival was associated with wide surgical resection with negative microscopic margins, adjuvant local radiation therapy, and presentation since 1970 (48% 5-year survival compared with 28% before 1970).
1935年至1985年间，梅奥诊所（明尼苏达州罗切斯特）的50名患者符合骨外尤因肉瘤的组织学标准。其中42例为软组织原发性肿瘤，无骨受累，构成了本次骨外尤因肉瘤临床行为及治疗回顾性研究的基础。患者中男性19例，女性23例（平均年龄22岁）。30例患者有转移记录，6例在初诊时即有转移，24例在之后长达11年出现转移，最常见转移至肺或骨。3例患者失访。35例患者中有16例（46%）出现局部复发。5年总生存率为39例中的15例（38.5%）。盆腔肿瘤、切除不彻底及存在转移性疾病患者生存率降低，而广泛手术切除且镜下切缘阴性、辅助性局部放疗以及1970年以后就诊的患者生存率提高（5年生存率48%，而1970年以前为28%）。
