Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830011, China.
Molecules. 2018 May 26;23(6):1279. doi: 10.3390/molecules23061279.
A phytochemical investigation of the stems of has led to an isolation of four new lignans, named kadsutherin E⁻H (⁻), together with two known lignans (⁻). The structures of the four new compounds were established on the basis of comprehensive spectroscopic analyses. Compounds ⁻ exhibited inhibition against adenosine diphosphate (ADP) induced platelet aggregation. Among the isolated compounds, kadsutherin F () showed the strongest anti-platelet aggregation activity with an inhibition of 49.47%.
从 茎中提取的植物化学物质分离得到四个新的木脂素，分别命名为 kadsutherin E⁻H（⁻），此外还有两个已知的木脂素（⁻）。根据综合光谱分析，确定了这四个新化合物的结构。化合物 ⁻ 对二磷酸腺苷（ADP）诱导的血小板聚集有抑制作用。在所分离的化合物中，kadsutherin F（）显示出最强的抗血小板聚集活性，抑制率为 49.47%。
