Demonstration of the organ preference of liver selected 'high metastatic' Lewis lung tumor cell line.

The experimental metastasis patterns of 'low metastatic' Lewis lung tumor (LLT) and liver selected 'high metastatic' LLT-HH were studied following their arterial dissemination. In previous reports it was shown that both tumor lines develop metastases only in the first encountered organ. Here the liver preference of the liver selected cell line is demonstrated. The model of two LLT cell lines can provide experimental evidence for both the 'mechanical' and 'seed and soil' theories of metastasis formation, depending on the site of tumor cell injection.