薄树芝子实体中的倍半萜。
Meroterpenoids from the fruiting bodies of Ganoderma theaecolum.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
Drug Discovery Pipeline & Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510530, PR China.
出版信息
Fitoterapia. 2018 Mar;125:273-280. doi: 10.1016/j.fitote.2018.01.015. Epub 2018 Feb 1.
A series of new terminal cyclohexane-type meroterpenoids, ganotheaecoloids A-N (1-6, 8-13, 15, and 16), along with three known ones (7, 14, and 17), were isolated from the dried fruiting bodies of Ganoderma theaecolum. Their chemical structures were identified by using spectroscopic data and computational methods. Biological activity of all the new meroterpenoids against COX-2 was evaluated in vitro, only ganotheaecoloid J (11) was found to have COX-2 inhibitory activity with IC value of 9.96μM.
从云芝（Ganoderma theaecolum）的干燥子实体中分离得到了一系列新的末端环己烷型倍半萜类化合物，即 ganotheaecoloids A-N（1-6、8-13、15 和 16），以及三个已知化合物（7、14 和 17）。采用光谱数据和计算方法确定了它们的化学结构。对所有新的倍半萜类化合物进行了体外 COX-2 抑制活性评价，仅 ganotheaecoloid J（11）具有 COX-2 抑制活性，IC 值为 9.96μM。
Zotero 插件