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骨密度与牙齿根尖外吸收

Bone Density and Dental External Apical Root Resorption.

作者信息

Iglesias-Linares Alejandro, Morford Lorri Ann, Hartsfield James Kennedy

机构信息

Department of Orthodontics, Complutense University of Madrid, Plaza Ramon y Cajal sn, Madrid, Spain.

University of Kentucky Center for the Biologic Basis of Oral/Systemic Diseases, 1095 Veterans Administration Drive, HSRB Room 414, Lexington, KY, 40536-0305, USA.

出版信息

Curr Osteoporos Rep. 2016 Dec;14(6):292-309. doi: 10.1007/s11914-016-0340-1.

DOI:10.1007/s11914-016-0340-1
PMID:27766484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5106316/
Abstract

When orthodontic patients desire shorter treatment times with aesthetic results and long-term stability, it is important for the orthodontist to understand the potential limitations and problems that may arise during standard and/or technology-assisted accelerated treatment. Bone density plays an important role in facilitating orthodontic tooth movement (OTM), such that reductions in bone density can significantly increase movement velocity. Lifestyle, genetic background, environmental factors, and disease status all can influence a patients' overall health and bone density. In some individuals, these factors may create specific conditions that influence systemic-wide bone metabolism. Both genetic variation and the onset of a bone-related disease can influence systemic bone density and local bone density, such as observed in the mandible and maxilla. These types of localized density changes can affect the rate of OTM and may also influence the risk of unwanted outcomes, i.e., the occurrence of dental external apical root resorption (EARR).

摘要

当正畸患者期望在获得美观效果和长期稳定性的同时缩短治疗时间时,正畸医生了解在标准和/或技术辅助的加速治疗过程中可能出现的潜在限制和问题非常重要。骨密度在促进正畸牙齿移动(OTM)中起着重要作用,因此骨密度降低会显著提高移动速度。生活方式、遗传背景、环境因素和疾病状态都会影响患者的整体健康和骨密度。在某些个体中,这些因素可能会创造影响全身骨代谢的特定条件。基因变异和骨相关疾病的发生都会影响全身骨密度和局部骨密度,如下颌骨和上颌骨中观察到的情况。这些类型的局部密度变化会影响OTM的速度,也可能影响不良后果的风险,即牙齿外部根尖吸收(EARR)的发生。

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本文引用的文献

1
Genetic determinants and postorthodontic external apical root resorption in Czech children.捷克儿童的遗传决定因素与正畸治疗后根尖外吸收
Oral Dis. 2017 Jan;23(1):29-35. doi: 10.1111/odi.12564. Epub 2016 Aug 29.
2
Genetic and clinical risk factors of root resorption associated with orthodontic treatment.正畸治疗相关牙根吸收的遗传和临床风险因素。
Am J Orthod Dentofacial Orthop. 2016 Aug;150(2):283-9. doi: 10.1016/j.ajodo.2015.12.028.
3
Links Between the Microbiome and Bone.微生物群与骨骼之间的联系
J Bone Miner Res. 2016 Sep;31(9):1638-46. doi: 10.1002/jbmr.2887. Epub 2016 Jul 26.
4
IRAK1 variant is protective for orthodontic-induced external apical root resorption.白细胞介素-1受体相关激酶1变体对正畸诱导的根尖外吸收具有保护作用。
Oral Dis. 2016 Oct;22(7):658-64. doi: 10.1111/odi.12514. Epub 2016 Jul 26.
5
Association of genetic polymorphism and external apical root resorption.基因多态性与根尖外吸收的关联
Angle Orthod. 2016 Nov;86(6):1042-1049. doi: 10.2319/011916-50.1. Epub 2016 May 5.
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Metal-dependent Deacetylases: Cancer and Epigenetic Regulators.金属依赖性脱乙酰酶:癌症与表观遗传调节因子
ACS Chem Biol. 2016 Mar 18;11(3):706-16. doi: 10.1021/acschembio.5b01067.
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The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations.美国国家骨质疏松基金会关于峰值骨量发育与生活方式因素的立场声明:系统评价与实施建议
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Am J Pathol. 2015 Dec;185(12):3338-48. doi: 10.1016/j.ajpath.2015.08.013.
10
Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia.与正畸治疗同时发生的根尖外吸收(EARR)相关的遗传和治疗相关风险因素。
Orthod Craniofac Res. 2015 Apr;18 Suppl 1(Suppl 1):71-82. doi: 10.1111/ocr.12078.