Bergman U, Dahl-Puustinen M L
Department of Clinical Pharmacology, Karolinska Institutet, Huddinge Hospital, Sweden.
Eur J Clin Pharmacol. 1989;36(6):621-3. doi: 10.1007/BF00637747.
Data on forged prescriptions in Sweden in 1982-1986 were studied as an indicator in an epidemiological survey of medication abuse. The annual number of prescription forgeries doubled during the 5-year period. Psychotropic drugs accounted for 62% and analgesics for 25% of all forgeries. Benzodiazepines were the major single drug group, comprising 52% of all forgeries during the period. The major benzodiazepines on the market in Sweden (diazepam, oxazepam, nitrazepam and flunitrazepam) were the subject of largest number of forgeries. When calculated in relation to the utilization (either total sales or the number of prescriptions), the analgesics codeine, pentazocine and ketobemidone were clearly at the head of the list, suggesting greater abuse liability of these drugs. It is suggested that the data on forged prescriptions can be used as a "signalling mechanism" in epidemiological surveillance of medication abuse, aimed at detecting changes in the prevalence as well as in the pattern of abuse.
1982年至1986年瑞典伪造处方的数据在一项药物滥用的流行病学调查中作为一项指标进行了研究。在这5年期间,处方伪造的年数量翻了一番。精神药物占所有伪造处方的62%,镇痛药占25%。苯二氮䓬类药物是主要的单一药物类别,在此期间占所有伪造处方的52%。瑞典市场上主要的苯二氮䓬类药物(地西泮、奥沙西泮、硝西泮和氟硝西泮)是伪造数量最多的对象。按照使用情况(总销售额或处方数量)计算,镇痛药可待因、喷他佐辛和凯托米酮明显位居前列,表明这些药物的滥用可能性更大。有人提出,伪造处方的数据可作为药物滥用流行病学监测中的一种“信号机制”,旨在发现滥用流行率以及滥用模式的变化。