Hall L M, Jordens J Z, Wang F
Department of Medical Microbiology, London Hospital Medical College.
Epidemiol Infect. 1989 Aug;103(1):183-92. doi: 10.1017/s095026880003048x.
A series of clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) from two hospitals in China was examined. Fragment patterns obtained by digestion of total cellular DNA with restriction enzymes were used to characterize the isolates, in combination with phage-typing, antibiotic resistance profile, and plasmid profile. Digestion of total cellular DNA with restriction enzymes was most useful in discriminating between isolates and yielded additional information on the relatedness of non-identical isolates. In one hospital a single strain, resistant to a large number of antibiotics, had apparently become endemic. In the second hospital a number of distinct but related strains were present. The isolates were also related but not identical to the strain of MRSA endemic at the London Hospital.
对来自中国两家医院的一系列耐甲氧西林金黄色葡萄球菌（MRSA）临床分离株进行了检测。用限制性内切酶消化总细胞DNA获得的片段模式，结合噬菌体分型、抗生素耐药谱和质粒图谱，用于对分离株进行特征分析。用限制性内切酶消化总细胞DNA在区分分离株方面最为有用，并能提供关于非同一分离株相关性的额外信息。在一家医院，一株对多种抗生素耐药的菌株显然已成为地方流行菌株。在另一家医院，存在一些不同但相关的菌株。这些分离株也与伦敦医院流行的MRSA菌株相关但不相同。
