耐甲氧西林金黄色葡萄球菌中的质粒介导的抗生素耐药性

Plasmid-mediated antibiotic resistance in methicillin-resistant Staphylococcus aureus.

作者信息

Lyon B R, May J W, Marshall J H, Skurray R A

出版信息

Med J Aust. 1982 May 29;1(11):468-9. doi: 10.5694/j.1326-5377.1982.tb132418.x.

DOI:10.5694/j.1326-5377.1982.tb132418.x

PMID:6920562

Abstract

Strains of methicillin-resistant Staphylococcus aureus (MRSA), isolated from clinical sources in Victoria, were screened for the presence of plasmid DNA. Resistance to gentamicin, kanamycin, and tobramycin was found to reside on an 18-megadalton plasmid, and resistance to chloramphenicol was mediated by a 3-megadalton plasmid. No extra-chromosomal locus was found for resistance to several other antibiotics, including methicillin. Local strains of MRSA differ from their international counterparts by the possession of extensive chromosomal resistance determinants. Together with those encoded on plasmids, these determinants are capable of neutralising almost all available antistaphylococcal antibiotics.

摘要

从维多利亚州临床样本中分离出的耐甲氧西林金黄色葡萄球菌（MRSA）菌株，被检测是否存在质粒DNA。对庆大霉素、卡那霉素和妥布霉素的耐药性存在于一个18兆道尔顿的质粒上，而对氯霉素的耐药性由一个3兆道尔顿的质粒介导。未发现对包括甲氧西林在内的其他几种抗生素耐药的染色体外位点。本地的MRSA菌株与国际上的菌株不同，它们拥有广泛的染色体耐药决定簇。与质粒上编码的那些决定簇一起，这些决定簇几乎能够中和所有现有的抗葡萄球菌抗生素。