基于具有强第二近红外窗口吸收的聚乙二醇化 CuBiS 三元半导体纳米棒的协同热放疗。
Synergistic thermoradiotherapy based on PEGylated CuBiS ternary semiconductor nanorods with strong absorption in the second near-infrared window.
机构信息
State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
The First People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai 200080, PR China.
出版信息
Biomaterials. 2017 Jan;112:164-175. doi: 10.1016/j.biomaterials.2016.10.024. Epub 2016 Oct 12.
In this work, we report a successful synthesis of copper bismuth sulfide nanorods (NRs) with broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, which can be used as a 1064 nm-laser-driven photothermal agent with the photothermal conversion efficiency of 40.7%, noticeably higher than most of the reported PTT agents working in NIR-II window. The as-prepared PEGylated CuBiS NRs were used as photoacoustic imaging (PAI) and CT imaging agents due to their strong NIR absorption and large X-ray attenuation coefficient of bismuth. We are the first to demonstrate that a small quantity of PEGylated CuBiS NRs in tumors can concentrate radiation energy and trigger mild PTT under NIR-II irradiation and thus, these particles could be used as a novel, synergistic thermoradiotheraputic agent that enhances the efficacy of radiotherapy.
在这项工作中，我们成功合成了具有广泛且强烈光吸收的铜铋硫化纳米棒（NRs），其光吸收范围从紫外线（UV）到近红外（NIR）波长，可作为 1064nm 激光驱动的光热剂，其光热转换效率为 40.7%，明显高于大多数在近红外二区（NIR-II）窗口工作的 PTT 试剂。由于铋的强近红外吸收和大 X 射线衰减系数，所制备的 PEG 化 CuBiS NRs 可用作光声成像（PAI）和 CT 成像试剂。我们首次证明，肿瘤中少量的 PEG 化 CuBiS NRs 可以集中辐射能，并在近红外二区照射下引发温和的 PTT，因此，这些颗粒可用作一种新型的协同热放疗试剂，增强放疗的疗效。
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