Gao M, Hao Y, Huang M X, Ma D Q, Chen Y, Luo H Y, Gao Y, Cao Z Q, Peng X, Yu G Y
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, PR China; Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, PR China.
2nd Dental Centre, Peking University School and Hospital of Stomatology, Beijing, PR China.
Int J Oral Maxillofac Surg. 2017 Mar;46(3):343-349. doi: 10.1016/j.ijom.2016.09.021. Epub 2016 Oct 19.
The aims of this study were to investigate the epidemiological and clinical characteristics of epithelial salivary gland tumours in a northern Chinese population and to evaluate the current TNM classification system. A demographic and descriptive analysis of 7190 epithelial salivary gland tumours was performed. There were 4654 benign tumours and 2536 malignant tumours. The percentage of tumours located in the parotid, submandibular, sublingual, and minor salivary glands was 62.66%, 9.92%, 2.57%, and 24.85%, respectively; 22.26%, 35.76%, 92.97%, and 61.89% of the tumours, respectively, were malignant. Over 90% in the tongue and maxillary sinus were malignant. Warthin tumour, salivary duct carcinoma, and squamous cell carcinoma were predominant in males, while basal cell adenoma, myoepithelioma, and pleomorphic adenoma were predominant in females. Further, 2.55% of the tumours were in children and adolescents: 44.81% of the tumours were malignant, as opposed to 35.02% in adults. According to the 7th TNM classification, the percentages of T3 and stage III tumours were approximately 10%. Salivary gland tumours show distribution patterns according to histological type, location, and patient age and sex. The limitations of the current TNM classification of salivary gland carcinoma should be considered and revisions made.
本研究旨在调查中国北方人群上皮性涎腺肿瘤的流行病学和临床特征，并评估当前的TNM分类系统。对7190例上皮性涎腺肿瘤进行了人口统计学和描述性分析。其中良性肿瘤4654例，恶性肿瘤2536例。位于腮腺、下颌下腺、舌下腺和小涎腺的肿瘤百分比分别为62.66%、9.92%、2.57%和24.85%；这些肿瘤的恶性率分别为22.26%、35.76%、92.97%和61.89%。舌和上颌窦的肿瘤恶性率超过90%。沃辛瘤、涎腺导管癌和鳞状细胞癌在男性中占主导地位，而基底细胞腺瘤、肌上皮瘤和多形性腺瘤在女性中占主导地位。此外，2.55%的肿瘤发生在儿童和青少年：其中44.81%为恶性肿瘤，而成人恶性肿瘤比例为35.02%。根据第7版TNM分类，T3期和III期肿瘤的比例约为10%。涎腺肿瘤根据组织学类型、部位、患者年龄和性别呈现出不同的分布模式。应考虑当前涎腺癌TNM分类的局限性并进行修订。
