Kwok Janette, Guo Mengbiao, Yang Wanling, Lee C K, Ho Jenny, Tang W H, Chan Y S, Middleton Derek, Lu L W, Chan Godfrey C F
Division of Transplantation and Immunogenetics, Queen Mary Hospital, Hong Kong.
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong.
Hum Immunol. 2016 Dec;77(12):1111-1112. doi: 10.1016/j.humimm.2016.10.005. Epub 2016 Oct 18.
HLA-A, -B, -C and -DRB1 gene and haplotype frequencies have been calculated from 7595 southern Chinese unrelated donors in a Hong Kong Bone Marrow Donor Registry. This is the first large-scale paper to report the distribution of A-C-B-DRB1 alleles in Hong Kong Chinese. This information is important for phylogenetic, comparative studies and estimating the optimal and cost-effective donor size and likelihood of obtaining appropriately matched donors for Chinese patients awaiting haematopoietic stem cell transplantation. The allele and haplotype data are available in the Allele Frequencies Net Database under the population name ''Hong Kong Chinese BMDR'' and the identifier (AFND003357).
香港骨髓捐赠者登记处对7595名中国南方无关供者的人类白细胞抗原A、B、C和DRB1基因及单倍型频率进行了计算。这是首篇大规模报道香港华人A-C-B-DRB1等位基因分布情况的论文。该信息对于系统发育、比较研究以及估算最佳且具成本效益的供者规模，以及为等待造血干细胞移植的中国患者找到匹配供者的可能性而言至关重要。等位基因和单倍型数据可在等位基因频率网络数据库中获取，种群名称为“香港华人骨髓捐赠者登记处”，标识符为(AFND003357)。
