Manor Sigal, Halagan Michael, Shriki Nira, Yaniv Isaac, Zisser Bracha, Maiers Martin, Madbouly Abeer, Stein Jerry
Ezer Mizion Bone Marrow Donor Registry, Petach Tikva, Israel.
Bioinformatics Research, National Marrow Donor Program, Minneapolis, MN, USA.
Hum Immunol. 2016 Dec;77(12):1114-1119. doi: 10.1016/j.humimm.2016.09.004. Epub 2016 Sep 17.
We have investigated HLA population alleles and haplotype frequencies for the ethnicities that comprise the contemporary population of Israel, using a large data set from the Ezer Mizion Bone Barrow Donor Registry. We genotyped 275,699 individuals at the HLA-A, -B and -DRB1 loci using HLA genotyping methods. HLA A∼B∼DRB1 haplotype frequencies were estimated from 19 sub-ethnic Jewish populations and other non-Jewish minorities using the maximum likelihood model, which accommodates typing ambiguities. We present overall and sub-ethnicity specific HLA diversity results of the registry, which will help guide a data-driven strategy for future registry expansion.
我们利用来自埃泽·米齐昂骨髓捐赠者登记处的大量数据集，对构成以色列当代人口的各民族的HLA群体等位基因和单倍型频率进行了调查。我们使用HLA基因分型方法，对275,699名个体的HLA - A、- B和 - DRB1位点进行了基因分型。使用考虑分型模糊性的最大似然模型，从19个亚族犹太人群体和其他非犹太少数群体中估计了HLA A∼B∼DRB1单倍型频率。我们展示了登记处总体及各亚族特定的HLA多样性结果，这将有助于指导未来登记处扩展的数据驱动策略。
