香港华人脐血库中3892份脐血样本的HLA - A、- B和 - DRB1基因分型及单倍型频率
HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry.
作者信息
Kwok Janette, Guo Mengbiao, Yang Wanling, Lee C K, Chan N K, Ho Jenny, Tang W H, Chan Y S, Middleton Derek, Lu L W, Chan Godfrey C F
机构信息
Division of Transplantation and Immunogenetics, Queen Mary Hospital, Hong Kong.
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong.
出版信息
Hum Immunol. 2016 Dec;77(12):1109-1110. doi: 10.1016/j.humimm.2016.10.006. Epub 2016 Oct 18.
HLA-A, -B and -DRB1 gene and haplotype frequencies have been calculated from 3892 southern Chinese unrelated cord blood units in a Hong Kong Cord Blood Registry. This is the first large-scale paper to report the distribution of A-B-DRB1 alleles in Hong Kong Chinese Cord Blood Units. This information is important for estimating the optimal and economically cost-effective donor size and likelihood of obtaining appropriately matched cord blood units for Chinese patients awaiting haematopoietic stem cell transplantation. The data are available in the Allele Frequencies Net Database under the population name ''Hong Kong Chinese Cord Blood Registry'' and the identifier (AFND003358).
已从香港脐带血库的3892份中国南方非亲属脐带血样本中计算出HLA - A、- B和 - DRB1基因及单倍型频率。这是首篇大规模报道香港中国脐带血库中A - B - DRB1等位基因分布的论文。这些信息对于估算等待造血干细胞移植的中国患者获得最佳且经济高效的供体规模以及找到合适配型脐带血样本的可能性至关重要。这些数据可在等位基因频率网络数据库中以“香港中国脐带血库”的种群名称及标识符（AFND003358）获取。
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