阿尔茨海默病中的触发受体表达上调分子（TREM）：遗传学与临床研究。

TREMs in Alzheimer's disease: Genetic and clinical investigations.

作者信息

Cheng Jia, Guo XiaoFeng, Zhang Tian, Zhong Li, Bu GuoJun, Chen XiaoFen

机构信息

Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.

出版信息

Clin Chim Acta. 2016 Dec 1;463:88-95. doi: 10.1016/j.cca.2016.10.022. Epub 2016 Oct 18.

DOI:10.1016/j.cca.2016.10.022

PMID:27769848

Abstract

Triggering receptor expressed on myeloid cells (TREMs) receptors constitute a family modulators in human innate immunity system that encode by a gene cluster. Rare variants in TREM2 were reported to be associated with significant Alzheimer's disease (AD) risk. However, inconsistent results were also reported in some studies of Non-European descents. Recently, the other TREM family members are also considered to involve in AD and cerebrospinal fluid (CSF) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease. In this review, we converged the data of genetic and clinical investigations to identify the clearer role of TREMs in AD. Here, comprehensively analyze of multidisciplinary fields highlights the contribution of TREMs locus to AD development.

摘要

髓系细胞表达的触发受体（TREMs）构成了人类先天免疫系统中的一个调节因子家族，由一个基因簇编码。据报道，TREM2中的罕见变异与显著的阿尔茨海默病（AD）风险相关。然而，在一些非欧洲血统的研究中也报道了不一致的结果。最近，其他TREM家族成员也被认为与AD有关，并且脑脊液（CSF）中可溶性形式的TREM2（sTREM2）水平也与疾病进展的反应有关。在本综述中，我们汇总了遗传和临床研究数据，以确定TREMs在AD中更明确的作用。在这里，对多学科领域的综合分析突出了TREMs基因座对AD发展的贡献。